Hydrolyzed Extensin

INCI: HYDROLYZED EXTENSIN

CAS Number
222400-33-1
Function
Skin conditioning; hair conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not on FDA prohibited/restricted lists

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Extremely data-poor with no published toxicology studies, CIR review, or SCCS opinion. Plant cell wall glycoprotein theoretically presents low risk, but comprehensive safety dossier would require acute dermal toxicity, sensitization (DPRA/KeratinoSens or HRIPT), and irritation data. Molecular weight characterization essential to rule out Type I hypersensitivity potential in this hydroxyproline-rich glycoprotein.

โš ๏ธ
Concern Level: Moderate

Regulatory Flags

potential-allergen natural-origin

Frequently Asked Questions

Is Hydrolyzed Extensin safe in cosmetics?

Extremely data-poor with no published toxicology studies, CIR review, or SCCS opinion. Plant cell wall glycoprotein theoretically presents low risk, but comprehensive safety dossier would require acute dermal toxicity, sensitization (DPRA/KeratinoSens or HRIPT), and irritation data. Molecular weight characterization essential to rule out Type I hypersensitivity potential in this hydroxyproline-rich glycoprotein. The EU classifies Hydrolyzed Extensin as "permitted". Safety rating: MODERATE.

Is Hydrolyzed Extensin allowed in the EU?

Hydrolyzed Extensin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydrolyzed Extensin do in cosmetics?

Hydrolyzed Extensin functions as: Skin conditioning; hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 222400-33-1.

What is the Margin of Safety for Hydrolyzed Extensin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Hydrolyzed Extensin in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hydrolyzed Extensin in your formulation.