Excellent Humectant Dermal Penetration

Sodium Hyaluronate Crosspolymer

INCI: SODIUM HYALURONATE CROSSPOLYMER

CAS Number
1186211-02-8
Function
Humectant, skin-conditioning, film-forming, thickener
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR Expert Panel: safe as used in cosmetics (reaffirmed March 2023). Self-crosslinked cosmetic grade โ€” no FDA PMA required (distinct from BDDE-crosslinked dermal fillers which are Class III medical devices).

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Sodium Hyaluronate Crosspolymer, relevant to systemic exposure and MoS calculations.

Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
Variable Da
Log P
-10.5
Systemic Absorption
no
Topical Bioavailability
0.5-2%
Safety Margin Factor
minimal

Source: J Cosmet Dermatol 2019

Expert Verdict

Advanced cosmetic HA form providing extended hydration through hyaluronidase-resistant hydrogel microparticle technology. Maintains water-solubility as a powder while offering superior longevity vs. linear HA. No chemical crosslinker (BDDE) concerns. CIR-reviewed safe as used. Distinct from medical-device filler HA โ€” no regulatory restrictions for topical cosmetic use.

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Concern Level: None

Frequently Asked Questions

Is Sodium Hyaluronate Crosspolymer safe in cosmetics?

Advanced cosmetic HA form providing extended hydration through hyaluronidase-resistant hydrogel microparticle technology. Maintains water-solubility as a powder while offering superior longevity vs. linear HA. No chemical crosslinker (BDDE) concerns. CIR-reviewed safe as used. Distinct from medical-device filler HA โ€” no regulatory restrictions for topical cosmetic use. The EU classifies Sodium Hyaluronate Crosspolymer as "permitted". Safety rating: EXCELLENT.

Is Sodium Hyaluronate Crosspolymer allowed in the EU?

Sodium Hyaluronate Crosspolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Hyaluronate Crosspolymer do in cosmetics?

Sodium Hyaluronate Crosspolymer functions as: Humectant, skin-conditioning, film-forming, thickener. It is classified as a Humectant in our database. CAS number: 1186211-02-8.

What is the Margin of Safety for Sodium Hyaluronate Crosspolymer?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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