Hydroxycitronellal-Indole Schiff Base

INCI: HYDROXYCITRONELLAL-INDOLE SCHIFF BASE

CAS Number
68527-79-7
Function
Perfuming (fragrance ingredient, declared as PARFUM)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific CFR restriction; subject to MoCRA fragrance allergen disclosure requirements

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hydrolysis liberates hydroxycitronellal (EU Annex III allergen); SCCS/RIFM safety assessed the parent but not the Schiff base individually; must be declared when total hydroxycitronellal exceeds 10 ppm (leave-on) or 100 ppm (rinse-off).

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is Hydroxycitronellal-Indole Schiff Base safe in cosmetics?

Hydrolysis liberates hydroxycitronellal (EU Annex III allergen); SCCS/RIFM safety assessed the parent but not the Schiff base individually; must be declared when total hydroxycitronellal exceeds 10 ppm (leave-on) or 100 ppm (rinse-off). The EU classifies Hydroxycitronellal-Indole Schiff Base as "restricted". Safety rating: MODERATE.

Is Hydroxycitronellal-Indole Schiff Base allowed in the EU?

Hydroxycitronellal-Indole Schiff Base EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxycitronellal-Indole Schiff Base do in cosmetics?

Hydroxycitronellal-Indole Schiff Base functions as: Perfuming (fragrance ingredient, declared as PARFUM). It is classified as a cosmetic ingredient in our database. CAS number: 68527-79-7.

What is the Margin of Safety for Hydroxycitronellal-Indole Schiff Base?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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