Hydroxyethyl Cyclodextrin

INCI: HYDROXYETHYL CYCLODEXTRIN

CAS Number
128446-32-2
Function
Complexing agent, solubilizer, stabilizer
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR; no CIR final report as standalone ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Complexation with other actives may alter their bioavailability; ensure no unintended enhancement of penetration of restricted ingredients in formulation

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Concern Level: Low

Frequently Asked Questions

Is Hydroxyethyl Cyclodextrin safe in cosmetics?

Complexation with other actives may alter their bioavailability; ensure no unintended enhancement of penetration of restricted ingredients in formulation The EU classifies Hydroxyethyl Cyclodextrin as "permitted". Safety rating: GOOD.

Is Hydroxyethyl Cyclodextrin allowed in the EU?

Hydroxyethyl Cyclodextrin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxyethyl Cyclodextrin do in cosmetics?

Hydroxyethyl Cyclodextrin functions as: Complexing agent, solubilizer, stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 128446-32-2.

What is the Margin of Safety for Hydroxyethyl Cyclodextrin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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