Excellent Cosmetic Ingredient

Hydroxypropyl Beta-Cyclodextrin

INCI: HYDROXYPROPYL BETA-CYCLODEXTRIN

CAS Number
128446-35-5
Function
Encapsulant; highly water-soluble inclusion complex former; solubilizer for poorly water-soluble cosmetic actives; stabilizer
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR Expert Panel concluded safe as used in cosmetics (October 2015). Not subject to FDA restriction. Parent beta-cyclodextrin has FDA GRAS status for food; HP-beta-CD is an approved USP/NF excipient.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hydroxypropyl Beta-Cyclodextrin (CAS 128446-35-5) is permitted in EU cosmetics and not listed in Annex II/III; CIR concluded safe as used in cosmetics with negligible systemic exposure and no sensitization concerns.

⚠️
Concern Level: None

Regulatory Flags

low-penetration chelating-agent excipient cir-assessed ema-reviewed

Frequently Asked Questions

Is Hydroxypropyl Beta-Cyclodextrin safe in cosmetics?

Hydroxypropyl Beta-Cyclodextrin (CAS 128446-35-5) is permitted in EU cosmetics and not listed in Annex II/III; CIR concluded safe as used in cosmetics with negligible systemic exposure and no sensitization concerns. The EU classifies Hydroxypropyl Beta-Cyclodextrin as "permitted". Safety rating: EXCELLENT.

Is Hydroxypropyl Beta-Cyclodextrin allowed in the EU?

Hydroxypropyl Beta-Cyclodextrin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxypropyl Beta-Cyclodextrin do in cosmetics?

Hydroxypropyl Beta-Cyclodextrin functions as: Encapsulant; highly water-soluble inclusion complex former; solubilizer for poorly water-soluble cosmetic actives; stabilizer. It is classified as a Cosmetic Ingredient in our database. CAS number: 128446-35-5.

What is the Margin of Safety for Hydroxypropyl Beta-Cyclodextrin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Hydroxypropyl Beta-Cyclodextrin compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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