Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Hydroxyproline. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
No significant concerns. It is a naturally occurring non-proteinogenic amino acid found in collagen. Generally well-tolerated. Key amino acid in Type I and III collagen; stimulates fibroblast activity and induces natural collagen production; contains hydroxyl groups that form hydrogen bonds with water, improving stratum corneum hydration; exhibits antioxidant activity against UV- and pollution-induced oxidative damage
Regulatory Flags
Frequently Asked Questions
Is Hydroxyproline safe in cosmetics?
No significant concerns. It is a naturally occurring non-proteinogenic amino acid found in collagen. Generally well-tolerated. Key amino acid in Type I and III collagen; stimulates fibroblast activity and induces natural collagen production; contains hydroxyl groups that form hydrogen bonds with water, improving stratum corneum hydration; exhibits antioxidant activity against UV- and pollution-induced oxidative damage The EU classifies Hydroxyproline as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Hydroxyproline allowed in the EU?
Hydroxyproline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyproline do in cosmetics?
Hydroxyproline functions as: Antistatic, Hair Conditioning, Skin Conditioning, Surfactant - Cleansing. It is classified as a cosmetic ingredient in our database. CAS number: 51-35-4.
What is the Margin of Safety for Hydroxyproline?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydroxyproline?
The NOAEL (No Observed Adverse Effect Level) for Hydroxyproline is 200 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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