Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for L-Hydroxyproline. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Key structural amino acid in collagen with skin-conditioning, hair-conditioning, and antistatic functions; supports skin firmness and hydration; excellent safety profile as an endogenous molecule
Regulatory Flags
Frequently Asked Questions
Is L-Hydroxyproline safe in cosmetics?
Key structural amino acid in collagen with skin-conditioning, hair-conditioning, and antistatic functions; supports skin firmness and hydration; excellent safety profile as an endogenous molecule The EU classifies L-Hydroxyproline as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is L-Hydroxyproline allowed in the EU?
L-Hydroxyproline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Hydroxyproline do in cosmetics?
L-Hydroxyproline functions as: Skin conditioning, Hair conditioning, Antistatic, Surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 51-35-4.
What is the Margin of Safety for L-Hydroxyproline?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Hydroxyproline?
The NOAEL (No Observed Adverse Effect Level) for L-Hydroxyproline is 200 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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