Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl
INCI: HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 25 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| LOAEL | 70 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
Expert Verdict
Reviewed by both the EU SCCP and the CIR Expert Panel. Potential for skin sensitization typical of phenylenediamine-class dyes; patch testing required. CIR concluded safe as used. Functions as a coupler in oxidative hair dye systems - reacts with primary intermediates (e.g., p-phenylenediamine, p-aminophenol) in the presence of hydrogen peroxide to form final dye chromophores; the hydroxypropyl and hydroxyethyl substituents improve solubility and reduce irritation potential relative to unsubs...
Regulatory Flags
Frequently Asked Questions
Is Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl safe in cosmetics?
Reviewed by both the EU SCCP and the CIR Expert Panel. Potential for skin sensitization typical of phenylenediamine-class dyes; patch testing required. CIR concluded safe as used. Functions as a coupler in oxidative hair dye systems - reacts with primary intermediates (e.g., p-phenylenediamine, p-aminophenol) in the presence of hydrogen peroxide to form final dye chromophores; the hydroxypropyl and hydroxyethyl substituents improve solubility and reduce irritation potential relative to unsubs... The EU classifies Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl as "restricted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl allowed in the EU?
Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl EU regulatory status: restricted. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl do in cosmetics?
Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl functions as: Hair Dyeing - oxidative hair dye coupler. It is classified as a cosmetic ingredient in our database. CAS number: 128729-28-2.
What is the Margin of Safety for Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl?
The NOAEL (No Observed Adverse Effect Level) for Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl is 25 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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