Hydroxypropyl-p-Phenylenediamine

INCI: HYDROXYPROPYL-P-PHENYLENEDIAMINE

CAS Number
73793-79-0 [^1_23]
Function
Oxidative hair dye (coupler/developer)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 2%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under coal tar hair dye exemption (FD&C Act ยง601(a)); CIR assessment covers p-phenylenediamine class

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

SCCS opinion reversed in 2024 after additional data; restricted to oxidative hair colour only with concentration limit of 2%; not permitted for direct skin contact or eyelash/eyebrow use due to eye irritation potential.

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Concern Level: High

Frequently Asked Questions

Is Hydroxypropyl-p-Phenylenediamine safe in cosmetics?

SCCS opinion reversed in 2024 after additional data; restricted to oxidative hair colour only with concentration limit of 2%; not permitted for direct skin contact or eyelash/eyebrow use due to eye irritation potential. The EU classifies Hydroxypropyl-p-Phenylenediamine as "restricted". Safety rating: MODERATE.

Is Hydroxypropyl-p-Phenylenediamine allowed in the EU?

Hydroxypropyl-p-Phenylenediamine EU regulatory status: restricted. Maximum allowed concentration: 2%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxypropyl-p-Phenylenediamine do in cosmetics?

Hydroxypropyl-p-Phenylenediamine functions as: Oxidative hair dye (coupler/developer). It is classified as a cosmetic ingredient in our database. CAS number: 73793-79-0 [^1_23].

What is the Margin of Safety for Hydroxypropyl-p-Phenylenediamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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