Regulatory Status
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Safety Data
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Expert Verdict
Hypericum Perforatum Extract contains hypericin and hyperforin responsible for antimicrobial and anti-inflammatory properties in wound-healing applications. EU: Hypericin is restricted under Annex III due to phototoxicity potential with concentration limits on hypericin content that must be addressed in CPSR. Formulations should be used as PM applications or with SPF ≥30 protection to mitigate phototoxicity risk. US: Permitted as cosmetic ingredient with no specific concentration restrictions, though phototoxicity is documented. Wound healing claims trigger drug classification in both EU and US.
Regulatory Flags
Frequently Asked Questions
Is Hypericum Perforatum Extract safe in cosmetics?
Hypericum Perforatum Extract contains hypericin and hyperforin responsible for antimicrobial and anti-inflammatory properties in wound-healing applications. EU: Hypericin is restricted under Annex III due to phototoxicity potential with concentration limits on hypericin content that must be addressed in CPSR. Formulations should be used as PM applications or with SPF ≥30 protection to mitigate phototoxicity risk. US: Permitted as cosmetic ingredient with no specific concentration restrictions, though phototoxicity is documented. Wound healing claims trigger drug classification in both EU and US. The EU classifies Hypericum Perforatum Extract as "restricted". Safety rating: MODERATE.
Is Hypericum Perforatum Extract allowed in the EU?
Hypericum Perforatum Extract EU regulatory status: restricted. Maximum allowed concentration: Concentration limits apply based on hypericin content; specific limit determined by extract hypericin quantification. This is based on EU Regulation 1223/2009 and its amendments.
What does Hypericum Perforatum Extract do in cosmetics?
Hypericum Perforatum Extract functions as: Antimicrobial, anti-inflammatory, wound healing support. Key actives hypericin and hyperforin provide antimicrobial and anti-inflammatory properties. Used in combination wound-healing formulations.. It is classified as a Active Ingredient in our database. CAS number: 84082-80-4.
What is the Margin of Safety for Hypericum Perforatum Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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