Is Hypericum Perforatum Extract safe in cosmetics?
Hypericum Perforatum Extract has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
MODERATE
Active Ingredient
Hypericum Perforatum Extract
Also known as: St. John's Wort extract, EINECS 282-026-4, Hypericum oil, hypericum perforatum leaf extract, Hypericum perforatum tincture
INCI: HYPERICUM PERFORATUM EXTRACT
Hypericum Perforatum Extract (CAS 84082-80-4) is a cosmetic active ingredient functioning as Antimicrobial, anti-inflammatory, wound healing support. Key actives hypericin. EU Regulation 1223/2009 status: restricted, max Concentration limits apply based on hypericin content; specific limit determined by extract hypericin quantification. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 84082-80-4 →
Function
Antimicrobial, anti-inflammatory, wound healing support. Key actives hypericin and hyperforin provide antimicrobial and anti-inflammatory properties. Used in combination wound-healing formulations.
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
restricted
EU Max Conc.
Concentration limits apply based on hypericin content; specific limit determined by extract hypericin quantification
US US Status
permitted
US Notes
Permitted as cosmetic ingredient. No specific FDA concentration restrictions. Phototoxicity risk from hypericin content should be addressed in CPSR/safety substantiation. Wound healing claims trigger drug classification.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hypericum Perforatum Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Antiperspirant
Astringent
Biocide
Deodorizer
Humectant
Softener and conditioner
Regulatory List Membership (1)
EU Regulated in Personal Care
Editorial summary
Preliminary editorial summary for Hypericum Perforatum Extract — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
natural-origin
phototoxic
hypericin-content
eu-restricted
antimicrobial
anti-inflammatory
combination-synergy
post-caesarean-evidence
claims-sensitive
pm-application-recommended
Known Synonyms
St. John's Wort extract
EINECS 282-026-4
Hypericum oil
hypericum perforatum leaf extract
Hypericum perforatum tincture
Chemical Function
Humectant
Biocide
Antioxidant
Astringent
Deodorizer
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
57
Frequently Asked Questions
Is Hypericum Perforatum Extract allowed in the EU?
Hypericum Perforatum Extract EU regulatory status: restricted. Maximum allowed concentration: Concentration limits apply based on hypericin content; specific limit determined by extract hypericin quantification. This is based on EU Regulation 1223/2009 and its amendments.
What does Hypericum Perforatum Extract do in cosmetics?
Hypericum Perforatum Extract functions as: Antimicrobial, anti-inflammatory, wound healing support. Key actives hypericin and hyperforin provide antimicrobial and anti-inflammatory properties. Used in combination wound-healing formulations.. It is classified as a Active Ingredient in our database. CAS number: 84082-80-4.
Is Hypericum Perforatum Extract used outside cosmetics?
Hypericum Perforatum Extract also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hypericum Perforatum Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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