Aluminum Zirconium Tetrachlorohydrex Gly

INCI: ALUMINUM ZIRCONIUM TETRACHLOROHYDREX GLY

CAS Number
134910-86-4
Function
antiperspirant, astringent, deodorant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
EU Max Conc. Annex III Entry 50: max 20% aluminum chlorohydrate (anhydrous); max 5.4% Zr as anhydrous ZrO2; Al:Zr atomic ratio between 2 and 10; not to be used on peeled, irritated, or damaged skin. SCCS/1613/19 concentration limits as equivalent Al: non-spray antiperspirant ≤6.25%, spray antiperspirant ≤10.60% (≥80% particles >10 µm), toothpaste ≤2.65%, lipstick ≤0.77%
🇺🇸 US Status permitted
US Notes Approved OTC antiperspirant active under 21 CFR 350; max 20% in OTC antiperspirant products; regulated as drug not cosmetic; labeling requires kidney disease warning and broken skin warning (21 CFR 350.50)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

EU-restricted under Annex III Entry 50 with defined concentration limits. Dermal absorption virtually zero per landmark AMS studies — systemic exposure from cosmetic use is negligible versus dietary background. No conclusive breast cancer, neurotoxicity, or CMR link. FDA OTC drug monograph approval at up to 20%. Fully compliant use requires staying within SCCS/1613/19 equivalent-Al limits per product category and adhering to Annex III conditions of use. Not certifiable under COSMOS/ECOCERT.

⚠️
Concern Level: Low

Regulatory Flags

eu-restricted otc-drug-us not-cosmos-certifiable annex-iii-entry-50

Frequently Asked Questions

Is Aluminum Zirconium Tetrachlorohydrex Gly safe in cosmetics?

EU-restricted under Annex III Entry 50 with defined concentration limits. Dermal absorption virtually zero per landmark AMS studies — systemic exposure from cosmetic use is negligible versus dietary background. No conclusive breast cancer, neurotoxicity, or CMR link. FDA OTC drug monograph approval at up to 20%. Fully compliant use requires staying within SCCS/1613/19 equivalent-Al limits per product category and adhering to Annex III conditions of use. Not certifiable under COSMOS/ECOCERT. The EU classifies Aluminum Zirconium Tetrachlorohydrex Gly as "restricted". Safety rating: GOOD.

Is Aluminum Zirconium Tetrachlorohydrex Gly allowed in the EU?

Aluminum Zirconium Tetrachlorohydrex Gly EU regulatory status: restricted. Maximum allowed concentration: Annex III Entry 50: max 20% aluminum chlorohydrate (anhydrous); max 5.4% Zr as anhydrous ZrO2; Al:Zr atomic ratio between 2 and 10; not to be used on peeled, irritated, or damaged skin. SCCS/1613/19 concentration limits as equivalent Al: non-spray antiperspirant ≤6.25%, spray antiperspirant ≤10.60% (≥80% particles >10 µm), toothpaste ≤2.65%, lipstick ≤0.77%. This is based on EU Regulation 1223/2009 and its amendments.

What does Aluminum Zirconium Tetrachlorohydrex Gly do in cosmetics?

Aluminum Zirconium Tetrachlorohydrex Gly functions as: antiperspirant, astringent, deodorant. It is classified as a Active Ingredient in our database. CAS number: 134910-86-4.

What is the Margin of Safety for Aluminum Zirconium Tetrachlorohydrex Gly?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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