Is Aluminum Zirconium Tetrachlorohydrex Gly safe in cosmetics?
Aluminum Zirconium Tetrachlorohydrex Gly has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Active Ingredient
Aluminum Zirconium Tetrachlorohydrex Gly
Also known as: Aluminum zirconium tetrachlorohydrex glycine complex, UNII-8O386558JE, reaction of aluminium zirconium tetrachlorohydrate (Al8Zr(OH)12Cl4.xH2O) and glycine
INCI: ALUMINUM ZIRCONIUM TETRACHLOROHYDREX GLY
Aluminum Zirconium Tetrachlorohydrex Gly (CAS 134910-86-4) is a cosmetic active ingredient functioning as antiperspirant, astringent, deodorant. EU Regulation 1223/2009 status: restricted, max Annex III Entry 50: max 20% aluminum chlorohydrate (anhydrous); max 5.4% Zr as anhydrous ZrO2; Al:Zr atomic ratio between 2 and 10; not to be used on peeled, irritated, or damaged skin. SCCS/1613/19 concentration limits as equivalent Al: non-spray antiperspirant ≤6.25%, spray antiperspirant ≤10.60% (≥80% particles >10 µm), toothpaste ≤2.65%, lipstick ≤0.77%. Industrial safety data is also available in th
View industrial chemical safety profile for CAS 134910-86-4 →
Auto-generated CPSR Part A draft with source citations
Function
antiperspirant, astringent, deodorant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
aluminum;2-aminoacetic acid;zirconium(4+);chloride;hydroxide;hydrate
InChIKey
WYANSMZYIOPJFV-UHFFFAOYSA-L
Regulatory Status
EU EU Status
restricted
EU Max Conc.
Annex III Entry 50: max 20% aluminum chlorohydrate (anhydrous); max 5.4% Zr as anhydrous ZrO2; Al:Zr atomic ratio between 2 and 10; not to be used on peeled, irritated, or damaged skin. SCCS/1613/19 concentration limits as equivalent Al: non-spray antiperspirant ≤6.25%, spray antiperspirant ≤10.60% (≥80% particles >10 µm), toothpaste ≤2.65%, lipstick ≤0.77%
US US Status
permitted
US Notes
Approved OTC antiperspirant active under 21 CFR 350; max 20% in OTC antiperspirant products; regulated as drug not cosmetic; labeling requires kidney disease warning and broken skin warning (21 CFR 350.50)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aluminum Zirconium Tetrachlorohydrex Gly.
Calculate MoS for your specific formulation with the MoS Calculator.
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Antiperspirant | 10–20 | 20 | CIR/FDA |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
deodorant
{"cas_number": "134910-86-4", "ingredient_class": "antiperspirant_active", "mechanism_of_action": "sweat_gland_blocking", "antiperspirant_efficacy_sweat_reduction_pct": "40-70", "deodorant_efficacy_hours": "48-72", "odor_reduction_pct": "80-95", "bacteriostatic": "yes", "bactericidal": "no", "target_bacteria": "broad_spectrum", "microbiome_impact": "broad", "axillary_microbiome_effect": "significa…
ecotoxicity
{"biodegradable": "no", "biodegradation_days": "non-biodegradable", "bioaccumulative": "yes", "aquatic_toxicity_level": "moderate", "coral_reef_safe": "unknown", "marine_toxicity": "moderate toxicity", "freshwater_toxicity": "metal accumulation", "soil_toxicity": "aluminum/zirconium accumulation", "endocrine_disruptor": "no", "persistent_organic_pollutant": "yes", "microplastic": "no", "nano_parti…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antiperspirant
Astringent
Deodorizer
Expert Verdict
Expert safety assessment and concern-level summary for Aluminum Zirconium Tetrachlorohydrex Gly.
Regulatory Flags
eu-restricted
otc-drug-us
not-cosmos-certifiable
annex-iii-entry-50
Known Synonyms
Aluminum zirconium tetrachlorohydrex glycine complex
UNII-8O386558JE
reaction of aluminium zirconium tetrachlorohydrate (Al8Zr(OH)12Cl4.xH2O) and glycine
Chemical Function
Astringent
Deodorizer
Antiperspirant
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
12
Frequently Asked Questions
Is Aluminum Zirconium Tetrachlorohydrex Gly allowed in the EU?
Aluminum Zirconium Tetrachlorohydrex Gly EU regulatory status: restricted. Maximum allowed concentration: Annex III Entry 50: max 20% aluminum chlorohydrate (anhydrous); max 5.4% Zr as anhydrous ZrO2; Al:Zr atomic ratio between 2 and 10; not to be used on peeled, irritated, or damaged skin. SCCS/1613/19 concentration limits as equivalent Al: non-spray antiperspirant ≤6.25%, spray antiperspirant ≤10.60% (≥80% particles >10 µm), toothpaste ≤2.65%, lipstick ≤0.77%. This is based on EU Regulation 1223/2009 and its amendments.
What does Aluminum Zirconium Tetrachlorohydrex Gly do in cosmetics?
Aluminum Zirconium Tetrachlorohydrex Gly functions as: antiperspirant, astringent, deodorant. It is classified as a Active Ingredient in our database. CAS number: 134910-86-4.
Is Aluminum Zirconium Tetrachlorohydrex Gly used outside cosmetics?
Aluminum Zirconium Tetrachlorohydrex Gly also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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MoS Calculator
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