Regulatory Status
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Safety Data
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Expert Verdict
Extremely limited cosmetic safety data primarily studied as nutraceutical/pharmaceutical; no SCCS opinion; no published HRIPT/patch test data for cosmetic use; PDE-5 inhibitory activity raises concerns about systemic pharmacological effects if absorbed; CPSR assessor would likely require supplier-provided toxicological dossier or challenge inclusion without adequate justification.
Frequently Asked Questions
Is Icariside II safe in cosmetics?
Extremely limited cosmetic safety data primarily studied as nutraceutical/pharmaceutical; no SCCS opinion; no published HRIPT/patch test data for cosmetic use; PDE-5 inhibitory activity raises concerns about systemic pharmacological effects if absorbed; CPSR assessor would likely require supplier-provided toxicological dossier or challenge inclusion without adequate justification. The EU classifies Icariside II as "prohibited". Safety rating: MODERATE.
Is Icariside II allowed in the EU?
Icariside II EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Icariside II do in cosmetics?
Icariside II functions as: Skin conditioning (flavonoid glycoside from Epimedium spp.). It is classified as a cosmetic ingredient in our database. CAS number: 113558-15-9 [^1_13][^1_14].
What is the Margin of Safety for Icariside II?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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