Is Inosine safe in cosmetics?
Inosine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Inosine
Also known as: EINECS 200-390-4, Hypoxanthine, 9-beta-D-ribofuranosyl-, beta-D-Ribofuranoside, hypoxanthine-9, Inosinum, UNII-5A614L51CT (+15 more)
INCI: INOSINE
Inosine (CAS 58-63-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning; skin protecting. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 58-63-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; skin protecting
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
InChIKey
UGQMRVRMYYASKQ-KQYNXXCUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not on FDA prohibited/restricted lists (21 CFR 700)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Inosine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Inosine.
Known Synonyms
EINECS 200-390-4
Hypoxanthine, 9-beta-D-ribofuranosyl-
beta-D-Ribofuranoside, hypoxanthine-9
Inosinum
UNII-5A614L51CT
(-)-Inosine
1,9-Dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one
1,9-Dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one
1,9-Dihydro-9-beta-delta-ribofuranosyl-6H-purin-6-one
9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one
9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
9-b-D-Ribofuranosyl-Hypoxanthine
9-b-D-Ribofuranosylhypoxanthine
9-beta-D-Ribofuranosyl-Hypoxanthine
9-beta-D-ribofuranosyl-9H-purin-6-ol
9-beta-D-ribofuranosylhypoxanthine
9-beta-delta-Ribofuranosyl-Hypoxanthine
9-beta-delta-Ribofuranosylhypoxanthine
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
INOSINE
ChEMBL ID
CHEMBL1556
Max Phase
3
Adverse Event Associations
6
Frequently Asked Questions
Is Inosine allowed in the EU?
Inosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Inosine do in cosmetics?
Inosine functions as: Skin conditioning; skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: 58-63-9.
Is Inosine used outside cosmetics?
Inosine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Biotin
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Chemical family
active / lipolytic / antioxidant
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