Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
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Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
๏ฌve adenosine ingredients reviewed in this report are safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Adenosine, Adenosine Phosphate, Adenosine Triphosphate, Disodium Adenosine Phosphate, and Disodium Adenosine Triphosphate Introd
Dermal Penetration Profile
Skin absorption and penetration characteristics of Adenosine, relevant to systemic exposure and MoS calculations.
Source: Skin Pharmacol Physiol 2007
Expert Verdict
CIR safe as used (2023). Japan quasi-drug wrinkle improvement. Korea MFDS functional cosmetic with wrinkle care at โฅ0.04%. Non-genotoxic (Ames negative). Non-sensitizing (HRIPT n=205). No Annex listings. Anti-wrinkle claims cross drug boundary in EU/US/China. COSMOS eligible via fermentation.
Regulatory Flags
Frequently Asked Questions
Is Adenosine safe in cosmetics?
CIR safe as used (2023). Japan quasi-drug wrinkle improvement. Korea MFDS functional cosmetic with wrinkle care at โฅ0.04%. Non-genotoxic (Ames negative). Non-sensitizing (HRIPT n=205). No Annex listings. Anti-wrinkle claims cross drug boundary in EU/US/China. COSMOS eligible via fermentation. The EU classifies Adenosine as "permitted". Safety rating: EXCELLENT. This ingredient has been reviewed by cir.
Is Adenosine allowed in the EU?
Adenosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Adenosine do in cosmetics?
Adenosine functions as: Skin-conditioning agent, anti-aging, purine nucleoside, collagen stimulator, anti-wrinkle agent, adenosine receptor agonist in fibroblasts. It is classified as a Active Ingredient in our database. CAS number: 58-61-7.
What is the Margin of Safety for Adenosine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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