Is Adenosine safe in cosmetics?
Adenosine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.
Adenosine
INCI: ADENOSINE
Adenosine (CAS 58-61-7) is a cosmetic active ingredient functioning as Skin-conditioning agent, anti-aging, purine nucleoside, collagen stimulator,. EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 58-61-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning agent, anti-aging, purine nucleoside, collagen stimulator, anti-wrinkle agent, adenosine receptor agonist in fibroblasts
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions. Anti-wrinkle claims must remain cosmetic-safe. Adenosine is also an Rx drug (Adenocard IV) but irrelevant to cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Adenosine.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: safe
five adenosine ingredients reviewed in this report are safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Adenosine, Adenosine Phosphate, Adenosine Triphosphate, Disodium Adenosine Phosphate, and Disodium Adenosine Triphosphate Introd
Dermal Penetration Profile
Skin absorption and penetration characteristics of Adenosine, relevant to systemic exposure and MoS calculations.
Absorption %
6-12%
Penetration Level
epidermis
Penetration Depth
epidermis
Molecular Weight
267.2 Da
Log P
-1.8
Systemic Absorption
minimal
Topical Bioavailability
4-10%
Safety Margin Factor
moderate
Vehicle Dependent
Yes — absorption varies by formulation
Source: Skin Pharmacol Physiol 2007
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Korea (Restricted): max 0.04
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Serum | 0.04–0.1 | 0.1 | CIR/Industry |
| Face Cream | 0.04–0.1 | 0.1 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "58-61-7", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_ac…
anti_aging
{"anti_aging_claim": "anti-wrinkle, collagen-boosting", "mechanism_of_action": "Specialized bioactive mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "15-25", "clinical_study_duration_weeks": "12", "sample_size": "28", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Specialized…
concentration
{"min_concentration_pct": "0.01", "max_concentration_pct": "0.1", "typical_concentration_pct": "0.05", "product_type": "Scalp Serum", "function_at_concentration": "Hair growth, anti-hair loss", "source": "Clinical literature; Supplier TDS"}
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "85", "estimated_cost_per_kg_usd_high": "160", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Korea/Japan", "bulk_discount_threshold_kg": "10", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Niacinamide…
dermal_absorption
{"molecular_weight_da": "267.2", "log_p_value": "-1.8", "skin_penetration_level": "epidermis", "penetration_depth": "epidermis", "absorption_pct": "6-12", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "4-10", "safety_margin_factor": "moderate", "source": "Ski…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "28-60", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "very low toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "palm_…
hair_care
{"hair_function": "scalp-care", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "kerati…
interactions
{"ingredient_2": "Niacinamide", "interaction_type": "synergistic", "severity": "beneficial", "effect": "Dual wrinkle reduction, enhanced skin smoothness", "recommendation": "Excellent combination; complementary mechanisms", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Adenosine.
Regulatory Flags
cir-safe-as-used-2023
japan-quasi-drug-wrinkle
korea-functional-cosmetic-0.04pct
non-genotoxic
non-sensitizing-hript-n205
no-annex-listing
anti-wrinkle-claims-jurisdiction-dependent
korea-method2-dec2025
cosmos-fermentation
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; non_food_use; Pesticides
pharmaceutical
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ADENOSINE
ChEMBL ID
CHEMBL477
Max Phase
4
Adverse Event Associations
138
Frequently Asked Questions
Is Adenosine allowed in the EU?
Adenosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Adenosine do in cosmetics?
Adenosine functions as: Skin-conditioning agent, anti-aging, purine nucleoside, collagen stimulator, anti-wrinkle agent, adenosine receptor agonist in fibroblasts. It is classified as a Active Ingredient in our database. CAS number: 58-61-7.
Is Adenosine used outside cosmetics?
Adenosine also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Adenosine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Biotin
Good
Chemical family
Scalp conditioning; hair care active
Caffeine
Good
Chemical family
active / lipolytic / antioxidant
Inosine
Good
Chemical family
Skin conditioning; skin protecting
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