Is Isoamyl Laurate safe in cosmetics?
Isoamyl Laurate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Emollient
Isoamyl Laurate
Also known as: EINECS 228-626-1, FEMA No. 2077, Isoamyl dodecanoate, Isopentyl dodecanoate, Isopentyl dodecylate (+3 more)
INCI: ISOAMYL LAURATE
Isoamyl Laurate (CAS 6309-51-9) is a cosmetic emollient functioning as emollient, skin-conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 6309-51-9 →
Auto-generated CPSR Part A draft with source citations
Function
emollient, skin-conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-methylbutyl dodecanoate
InChIKey
FVKRIDSRWFEQME-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA food additive approved (21 CFR 172.515). JECFA no safety concern as flavoring.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isoamyl Laurate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
9 property records from structured ingredient metadata.
comedogenicity_detail
{"comedogenicity_rating": "1", "irritancy_rating": "0", "skin_type_suitability": "all,oily,combination,normal,acne-prone", "acne_safe": "yes", "source": "Natural-origin ester"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "22", "estimated_cost_per_kg_usd_high": "40", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Europe", "bulk_discount_threshold_kg": "150", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Cyclomethicone…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "28-60", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "pa…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "10-11", "co_emulsifier_pairs": "polysorbate_20,laureth_4", "optimal_oil_phase_pct": "10-30", "optimal_water_phase_pct": "70-90", "droplet_size_range_um": "1-20", "creaming_resistance": "good", "coalescence_resistance": "good", "ostwald_ripening_resistance": "moderate", "freeze_thaw_stability": "moderate", "rheology_modifier_type": …
lipid
{"cas_number": "6309-51-9", "lipid_class": "ester", "botanical_source": "synthetic/derived", "plant_part": "derived", "extraction_method": "refined", "fatty_acid_profile_main_pct": "lauric ester", "omega_classification": "saturated", "comedogenicity_rating_0_5": "1", "absorption_rate": "fast", "skin_feel": "dry", "spreadability": "excellent", "emollient_grade": "A_excellent", "primary_application"…
ph_stability
{"optimal_ph_min": "3.0", "optimal_ph_max": "10.0", "stable_ph_min": "3.0", "stable_ph_max": "11.0", "ph_dependent_function": "Natural-derived emollient", "formulation_note": "Lightweight", "source": "Formulation literature"}
sensory
{"silky": "light", "smooth, glides easily": "smooth, light", "dry-touch, non-greasy": "dry-touch, soft", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "excellent", "no": "no", "yes": "no", "1.40": "1.44", "transparent": "transparent", "colorless": "colorless", "excellent": "excellent", "light": "light", "synthetic": "synthetic"}
silicone
{"cas_number": "Not silicone", "silicone_class": "other", "molecular_weight_Da": "270.0", "viscosity_cSt": "8", "volatility": "non_volatile", "evaporation_rate_relative_to_D5": "0.18", "refractive_index": "1.438", "specific_gravity": "0.862", "flash_point_C": "118.0", "surface_tension_mN_m": "26.2", "spreading_coefficient": "3.5", "film_forming_ability": "good", "skin_feel": "light", "slip_and_gli…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
182
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOPENTYL LAURATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Isoamyl Laurate.
Regulatory Flags
cosmos-eligible
silicone-alternative
d5-alternative
plant-derived
natural
ester
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
EINECS 228-626-1
FEMA No. 2077
Isoamyl dodecanoate
Isopentyl dodecanoate
Isopentyl dodecylate
Lauric acid, isopentyl ester
NSC 42577
UNII-M1SLX00M3M
Chemical Function
Softener and conditioner
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ISOAMYL LAURATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Isoamyl Laurate allowed in the EU?
Isoamyl Laurate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isoamyl Laurate do in cosmetics?
Isoamyl Laurate functions as: emollient, skin-conditioning. It is classified as a Emollient in our database. CAS number: 6309-51-9.
Is Isoamyl Laurate used outside cosmetics?
Isoamyl Laurate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isoamyl Laurate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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