Isobutyl Methylbutyrate

INCI: ISOBUTYL METHYLBUTYRATE

CAS Number
2445-67-2 (verify — this is isobutyl 2-methylbutyrate; confirm isomer with supplier)
Function
Fragrance
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — FEMA GRAS as flavoring substance; not restricted under 21 CFR for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Minimal concerns at typical fragrance use levels (generally <1%); volatile with flash point considerations for manufacturing; confirm isomer identity with supplier.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is Isobutyl Methylbutyrate safe in cosmetics?

Minimal concerns at typical fragrance use levels (generally <1%); volatile with flash point considerations for manufacturing; confirm isomer identity with supplier. The EU classifies Isobutyl Methylbutyrate as "permitted". Safety rating: GOOD.

Is Isobutyl Methylbutyrate allowed in the EU?

Isobutyl Methylbutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isobutyl Methylbutyrate do in cosmetics?

Isobutyl Methylbutyrate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 2445-67-2 (verify — this is isobutyl 2-methylbutyrate; confirm isomer with supplier).

What is the Margin of Safety for Isobutyl Methylbutyrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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