Isoleptospermone

INCI: ISOLEPTOSPERMONE

CAS Number
5009-05-2 (deprecated CAS: 7375-66-8)
Function
Hair conditioning, skin conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR restriction; not CIR-reviewed individually

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Monoterpenoid (β-triketone) from Leptospermum scoparium (mānuka) with significant data gaps; oral, dermal, and inhalation toxicity not determined, requiring custom testing or detailed read-across justification from related β-triketones for CPSR completion.

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Concern Level: High

Frequently Asked Questions

Is Isoleptospermone safe in cosmetics?

Monoterpenoid (β-triketone) from Leptospermum scoparium (mānuka) with significant data gaps; oral, dermal, and inhalation toxicity not determined, requiring custom testing or detailed read-across justification from related β-triketones for CPSR completion. The EU classifies Isoleptospermone as "permitted". Safety rating: MODERATE.

Is Isoleptospermone allowed in the EU?

Isoleptospermone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isoleptospermone do in cosmetics?

Isoleptospermone functions as: Hair conditioning, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5009-05-2 (deprecated CAS: 7375-66-8).

What is the Margin of Safety for Isoleptospermone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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