Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Isomerized Safflower Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 15000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 12628 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
| NOAEL | 3636 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| dose_tested | 12628 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
Expert Verdict
Hepatocellular hypertrophy observed in rats at high concentrations in subchronic studies; polyunsaturated content requires antioxidant protection in finished formulations; genotoxicity negative.
Frequently Asked Questions
Is Isomerized Safflower Acid safe in cosmetics?
Hepatocellular hypertrophy observed in rats at high concentrations in subchronic studies; polyunsaturated content requires antioxidant protection in finished formulations; genotoxicity negative. The EU classifies Isomerized Safflower Acid as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is Isomerized Safflower Acid allowed in the EU?
Isomerized Safflower Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isomerized Safflower Acid do in cosmetics?
Isomerized Safflower Acid functions as: Skin Conditioning Agent. It is classified as a cosmetic ingredient in our database. CAS number: 121250-47-3.
What is the Margin of Safety for Isomerized Safflower Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isomerized Safflower Acid?
The NOAEL (No Observed Adverse Effect Level) for Isomerized Safflower Acid is 15000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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