Is Isoniacinamide safe in cosmetics?
Isoniacinamide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isoniacinamide
Also known as: 5-22-02-00195, BRN 0002173, 4-Carbamoylpyridine, EINECS 215-926-2, gamma-Pyridinecarboxamide (+6 more)
INCI: ISONIACINAMIDE
Isoniacinamide (CAS 1453-82-3) is a cosmetic cosmetic ingredient functioning as Skin Conditioning (structural isomer of Niacinamide). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1453-82-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning (structural isomer of Niacinamide)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
pyridine-4-carboxamide
InChIKey
VFQXVTODMYMSMJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction. Note: Niacinamide (3-isomer) has full CIR clearance; this 4-isomer does NOT share that CIR review.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isoniacinamide.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Isoniacinamide.
Known Synonyms
5-22-02-00195
BRN 0002173
4-Carbamoylpyridine
EINECS 215-926-2
gamma-Pyridinecarboxamide
UNII-4H3BH6YX9Q
4-pyridinecarboxamide
Isonicotineamide
isn
isonicotinic acid amide
pyridine-4-carboxylic acid amide
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL271717
Frequently Asked Questions
Is Isoniacinamide allowed in the EU?
Isoniacinamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isoniacinamide do in cosmetics?
Isoniacinamide functions as: Skin Conditioning (structural isomer of Niacinamide). It is classified as a cosmetic ingredient in our database. CAS number: 1453-82-3.
Is Isoniacinamide used outside cosmetics?
Isoniacinamide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isoniacinamide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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