Regulatory Status
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Safety Data
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Expert Verdict
Not the same as Niacinamide. The CIR safety assessment covers niacinamide (nicotinamide, pyridine-3-carboxamide), NOT isonicotinamide. Biological activity differs — isonicotinamide is pharmacologically related to isoniazid (anti-TB drug) and has different receptor binding. A CPSR assessor will likely require a full read-across dossier with justification, or standalone tox data. Do not cite the niacinamide CIR report as direct safety evidence for this ingredient.
Frequently Asked Questions
Is Isoniacinamide safe in cosmetics?
Not the same as Niacinamide. The CIR safety assessment covers niacinamide (nicotinamide, pyridine-3-carboxamide), NOT isonicotinamide. Biological activity differs — isonicotinamide is pharmacologically related to isoniazid (anti-TB drug) and has different receptor binding. A CPSR assessor will likely require a full read-across dossier with justification, or standalone tox data. Do not cite the niacinamide CIR report as direct safety evidence for this ingredient. The EU classifies Isoniacinamide as "permitted". Safety rating: MODERATE.
Is Isoniacinamide allowed in the EU?
Isoniacinamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isoniacinamide do in cosmetics?
Isoniacinamide functions as: Skin Conditioning (structural isomer of Niacinamide). It is classified as a cosmetic ingredient in our database. CAS number: 1453-82-3.
What is the Margin of Safety for Isoniacinamide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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