Is Isooctyl Thioglycolate safe in cosmetics?
Isooctyl Thioglycolate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Isooctyl Thioglycolate
Also known as: Isooctyl alcohol, mercaptoacetate, Thioglycolic acid isooctyl ester, Acetic acid, mercapto-, isooctyl ester, Acetic acid, 2-mercapto-, isooctyl ester, Mercaptoacetate d'isooctyle (+9 more)
INCI: ISOOCTYL THIOGLYCOLATE
Isooctyl Thioglycolate (CAS 25103-09-7) is a cosmetic cosmetic ingredient functioning as Depilatory / hair-waving reducing agent (thioglycolic acid ester). EU Regulation 1223/2009 status: prohibited, max 8%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 25103-09-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isooctyl Thioglycolate is prohibited in EU cosmetics at max 8% but has active industrial GHS classifications (H302, H317, H319, H400, H410, H412).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Depilatory / hair-waving reducing agent (thioglycolic acid ester)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
6-methylheptyl 2-sulfanylacetate
InChIKey
RZBBHEJLECUBJT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
8%
US US Status
permitted
US Notes
Permitted with labeling requirements — 21 CFR 700.18 requires specific cautionary statements for thioglycolate-containing products
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isooctyl Thioglycolate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hair waving or straightening
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for Isooctyl Thioglycolate.
Known Synonyms
Isooctyl alcohol, mercaptoacetate
Thioglycolic acid isooctyl ester
Acetic acid, mercapto-, isooctyl ester
Acetic acid, 2-mercapto-, isooctyl ester
Mercaptoacetate d'isooctyle
isooctyl mercaptoacetate
Isooctylmercaptoacetat
mercaptoacetato de isooctilo
ISOOCTYLTHIOGLYCOLATE
THIOGLYCOLATE, ISOOCTYL
iso-octyl mercaptoacetate
EINECS 246-613-9
NSC 9590
UNII-3404M9ZDTB
Chemical Function
Hair waving or straightening
Viscosity modifier
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1889775
Frequently Asked Questions
Is Isooctyl Thioglycolate allowed in the EU?
Isooctyl Thioglycolate EU regulatory status: prohibited. Maximum allowed concentration: 8%. This is based on EU Regulation 1223/2009 and its amendments.
What does Isooctyl Thioglycolate do in cosmetics?
Isooctyl Thioglycolate functions as: Depilatory / hair-waving reducing agent (thioglycolic acid ester). It is classified as a cosmetic ingredient in our database. CAS number: 25103-09-7.
Is Isooctyl Thioglycolate used outside cosmetics?
Isooctyl Thioglycolate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isooctyl Thioglycolate have different safety status in cosmetics vs industrial chemicals?
Isooctyl Thioglycolate is prohibited in EU cosmetics at max 8% but has active industrial GHS classifications (H302, H317, H319, H400, H410, H412).
Compliance Tools
Check Isooctyl Thioglycolate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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