Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Isopropyl Citrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 530 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 2650 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2550 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| NOAEL | 15 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 530 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 530 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 2650 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 2550 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| dose_tested | 15 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| dose_tested | 530 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
Expert Verdict
Well-established safety profile across food and cosmetic applications; no significant toxicological flags; metabolises to citric acid and isopropyl alcohol, both well-characterised
Regulatory Flags
Frequently Asked Questions
Is Isopropyl Citrate safe in cosmetics?
Well-established safety profile across food and cosmetic applications; no significant toxicological flags; metabolises to citric acid and isopropyl alcohol, both well-characterised The EU classifies Isopropyl Citrate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Isopropyl Citrate allowed in the EU?
Isopropyl Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl Citrate do in cosmetics?
Isopropyl Citrate functions as: Antioxidant, antioxidant synergist, chelating agent, plasticizer. It is classified as a cosmetic ingredient in our database. CAS number: 1321-57-9.
What is the Margin of Safety for Isopropyl Citrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Isopropyl Citrate?
The NOAEL (No Observed Adverse Effect Level) for Isopropyl Citrate is 530 mg/kg bw/day based on a Reproductive study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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