Is Isopropyl Citrate safe in cosmetics?
Isopropyl Citrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Cosmetic Ingredient
Isopropyl Citrate
INCI: ISOPROPYL CITRATE
Isopropyl Citrate (CAS 1321-57-9) is a cosmetic cosmetic ingredient functioning as Antioxidant, antioxidant synergist, chelating agent, plasticizer. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
Function
Antioxidant, antioxidant synergist, chelating agent, plasticizer
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-hydroxy-2-(2-oxo-2-propan-2-yloxyethyl)butanedioic acid
InChIKey
SKHXHUZZFVMERR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; GRAS as food additive; no restriction under 21 CFR for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropyl Citrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Plasticizer
Processing aids not otherwise specified
Solvent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Isopropyl Citrate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fda_food_additive
Chemical Function
Solvent
Plasticizer
Chelating agent
Processing aids not otherwise specified
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
MONOISOPROPYL CITRATE
Food Category
food_additive
Frequently Asked Questions
Is Isopropyl Citrate allowed in the EU?
Isopropyl Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl Citrate do in cosmetics?
Isopropyl Citrate functions as: Antioxidant, antioxidant synergist, chelating agent, plasticizer. It is classified as a cosmetic ingredient in our database. CAS number: 1321-57-9.
Is Isopropyl Citrate used outside cosmetics?
Isopropyl Citrate also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isopropyl Citrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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