Regulatory Status
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Safety Data
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Expert Verdict
Major data gap. Maleate esters are α,β-unsaturated carbonyl compounds with potential for Michael addition reactivity — possible skin sensitization via haptenation; no CIR or SCCS review; no assigned cosmetic function in EU CosIng; extremely limited cosmetic use history; would require full toxicology dossier including irritation, sensitization, and genotoxicity studies before regulatory approval.
Regulatory Flags
Frequently Asked Questions
Is Isopropyl Maleate safe in cosmetics?
Major data gap. Maleate esters are α,β-unsaturated carbonyl compounds with potential for Michael addition reactivity — possible skin sensitization via haptenation; no CIR or SCCS review; no assigned cosmetic function in EU CosIng; extremely limited cosmetic use history; would require full toxicology dossier including irritation, sensitization, and genotoxicity studies before regulatory approval. The EU classifies Isopropyl Maleate as "prohibited". Safety rating: POOR.
Is Isopropyl Maleate allowed in the EU?
Isopropyl Maleate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl Maleate do in cosmetics?
Isopropyl Maleate functions as: Not reported in CosIng cosmetic function database. It is classified as a cosmetic ingredient in our database. CAS number: 924-83-4.
What is the Margin of Safety for Isopropyl Maleate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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