Regulatory Status
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Safety Data
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Expert Verdict
Potent vasodilator causing localized erythema, flushing, and warming via prostaglandin-dependent pathway; classified as skin irritant; high dermal penetration requires critical margin of safety calculation; contraindicated on compromised or sensitive skin and requires tight concentration control.
Frequently Asked Questions
Is Isopropyl Nicotinate safe in cosmetics?
Potent vasodilator causing localized erythema, flushing, and warming via prostaglandin-dependent pathway; classified as skin irritant; high dermal penetration requires critical margin of safety calculation; contraindicated on compromised or sensitive skin and requires tight concentration control. The EU classifies Isopropyl Nicotinate as "restricted". Safety rating: MODERATE.
Is Isopropyl Nicotinate allowed in the EU?
Isopropyl Nicotinate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl Nicotinate do in cosmetics?
Isopropyl Nicotinate functions as: Skin conditioning agent (vasodilator / rubefacient). It is classified as a cosmetic ingredient in our database. CAS number: 553-60-6.
What is the Margin of Safety for Isopropyl Nicotinate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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