Isopropyl-p-Cresol

INCI: ISOPROPYL-P-CRESOL

CAS Number
4427-56-9
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - CIR (Cosmetic Ingredient Review) determined safe at concentrations โ‰ค0.5%

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR safe up to 0.5% - the 0.5% cap was set to prevent chemical leukoderma (depigmentation); related compound p-Cresol raises stronger sensitization and skin-whitening concerns; potential skin sensitizer at higher concentrations. Structurally related to thymol (isopropyl-m-cresol) and carvacrol; pungent odor; thymol is a natural analog found in thyme (Thymus vulgaris) essential oil

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is Isopropyl-p-Cresol safe in cosmetics?

CIR safe up to 0.5% - the 0.5% cap was set to prevent chemical leukoderma (depigmentation); related compound p-Cresol raises stronger sensitization and skin-whitening concerns; potential skin sensitizer at higher concentrations. Structurally related to thymol (isopropyl-m-cresol) and carvacrol; pungent odor; thymol is a natural analog found in thyme (Thymus vulgaris) essential oil The EU classifies Isopropyl-p-Cresol as "permitted". Safety rating: MODERATE.

Is Isopropyl-p-Cresol allowed in the EU?

Isopropyl-p-Cresol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isopropyl-p-Cresol do in cosmetics?

Isopropyl-p-Cresol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 4427-56-9.

What is the Margin of Safety for Isopropyl-p-Cresol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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