Is Isopropyl-p-Cresol safe in cosmetics?
Isopropyl-p-Cresol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isopropyl-p-Cresol
Also known as: 2-Isopropyl-4-methylphenol, Phenol, 4-methyl-2-(1-methylethyl)-, BRN 1860557, p-Cresol, 2-isopropyl-, m-Cymen-4-ol (+5 more)
INCI: ISOPROPYL-P-CRESOL
Isopropyl-p-Cresol (CAS 4427-56-9) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 4427-56-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-methyl-2-propan-2-ylphenol
InChIKey
DSTPUJAJSXTJHM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - CIR (Cosmetic Ingredient Review) determined safe at concentrations ≤0.5%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropyl-p-Cresol.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | permitted_preservative | 0.1 | all cosmetics |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isopropyl-p-Cresol.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
2-Isopropyl-4-methylphenol
Phenol, 4-methyl-2-(1-methylethyl)-
BRN 1860557
p-Cresol, 2-isopropyl-
m-Cymen-4-ol
EINECS 224-611-9
1-Hydroxy-4-methyl-2-isopropylbenzene
4-Methyl-2-isopropylphenol
NSC 62110
UNII-RIM60IN3PY
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ISOTHYMOL
ChEMBL ID
CHEMBL2288299
Frequently Asked Questions
Is Isopropyl-p-Cresol allowed in the EU?
Isopropyl-p-Cresol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl-p-Cresol do in cosmetics?
Isopropyl-p-Cresol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 4427-56-9.
Is Isopropyl-p-Cresol used outside cosmetics?
Isopropyl-p-Cresol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isopropyl-p-Cresol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
ISOBORNYL DIPROPYLENE GLYCOL ETHERS
Good
Browse nearby
Antifoaming, Emulsion Stabilising, So...
ISOBUTYL METHACRYLATE/TRIFLUOROETHYLMETHACRYLATE/BIS-HYDROXYPROPYL DIMETHICONE ACRYLATE COPOLYMER
Good
Browse nearby
Film Forming, Hair Fixing
ISOBUTYLMETHACRYLATE/TRIFLUOROETHYLMETHACRYLATE/BIS-HYDROXYPROPYL DIMETHICONE ACRYLATE COPOLYMER
Good
Browse nearby
Film Forming, Hair Fixing, Skin Condi...
Is Isopropyl-p-Cresol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Isopropyl-p-Cresol in your formulation.