Is Isopropyl Phenylacetate safe in cosmetics?
Isopropyl Phenylacetate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isopropyl Phenylacetate
Also known as: Acetic acid, phenyl-, isopropyl ester, Isopropyl alpha-toluate, 1-Methylethyl benzeneacetate, Benzeneacetic acid, 1-methylethyl ester, EINECS 225-468-5 (+2 more)
INCI: ISOPROPYL PHENYLACETATE
Isopropyl Phenylacetate (CAS 4861-85-2) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming); also used as a synthetic flavoring agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 4861-85-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (perfuming); also used as a synthetic flavoring agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
propan-2-yl 2-phenylacetate
InChIKey
SSMBXPJYHMZLOJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - FEMA GRAS \#2956; approved for use in foods and cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropyl Phenylacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1011
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOPROPYL alpha-TOLUATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOPROPYL PHENYLACETATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Isopropyl Phenylacetate.
Regulatory Flags
potential-allergen
fragrance-component
fda_food_additive
jecfa_safe
Known Synonyms
Acetic acid, phenyl-, isopropyl ester
Isopropyl alpha-toluate
1-Methylethyl benzeneacetate
Benzeneacetic acid, 1-methylethyl ester
EINECS 225-468-5
FEMA No. 2956
UNII-A8L7NAJ0YO
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1449867
Frequently Asked Questions
Is Isopropyl Phenylacetate allowed in the EU?
Isopropyl Phenylacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl Phenylacetate do in cosmetics?
Isopropyl Phenylacetate functions as: Fragrance (perfuming); also used as a synthetic flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 4861-85-2.
Is Isopropyl Phenylacetate used outside cosmetics?
Isopropyl Phenylacetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isopropyl Phenylacetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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