Is Isopropylcyclohexanol safe in cosmetics?
Isopropylcyclohexanol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isopropylcyclohexanol
Also known as: 4-iso-Propylcyclohexanol, p-Isopropylcyclohexanol, Cyclohexanol, 4-(1-methylethyl)-, Cyclohexanol, p-isopropyl-, 4-(1-Methylethyl)cyclohexanol (+6 more)
INCI: 4-ISOPROPYLCYCLOHEXANOL
Isopropylcyclohexanol (CAS 4621-04-9) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 4621-04-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isopropylcyclohexanol is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-propan-2-ylcyclohexan-1-ol
InChIKey
DKKRDMLKVSKFMJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropylcyclohexanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
550 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [150] Kligman AM (1975): Report to RIFM, 9 April, unpublished.
HRIPT Human Patch Test Studies
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3375 | - | - |
| HRIPT | - | 0 | 550 | - | - |
| HRIPT | - | 0 | - | - | - |
| HRIPT | - | 0 | 2000 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isopropylcyclohexanol.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
4-iso-Propylcyclohexanol
p-Isopropylcyclohexanol
Cyclohexanol, 4-(1-methylethyl)-
Cyclohexanol, p-isopropyl-
4-(1-Methylethyl)cyclohexanol
2-06-00-00035
BRN 2322224
EINECS 225-035-0
NSC 21123
Apo patchone
Folrosia
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Isopropylcyclohexanol allowed in the EU?
Isopropylcyclohexanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropylcyclohexanol do in cosmetics?
Isopropylcyclohexanol functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 4621-04-9.
Is Isopropylcyclohexanol used outside cosmetics?
Isopropylcyclohexanol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isopropylcyclohexanol have different safety status in cosmetics vs industrial chemicals?
Isopropylcyclohexanol is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isopropylcyclohexanol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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