Is Isopropylmethylhexenal safe in cosmetics?
Isopropylmethylhexenal has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isopropylmethylhexenal
Also known as: 2-Hexenal, 2-isopropyl-5-methyl-, 2-Isopropyl-5-methyl-2-hexenal, 2-Isopropyl-5-methyl-2-hexen-1-al, 5-Methyl-2-(1-methylethyl)-2-hexenal, 2-Isopropyl-5-methylhex-2-enal (+10 more)
INCI: ISOPROPYLMETHYLHEXENAL
Isopropylmethylhexenal (CAS 35158-25-9) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 35158-25-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
5-methyl-2-propan-2-ylhex-2-enal
InChIKey
IOLQAHFPDADCHJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA 3406; no CFR prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropylmethylhexenal.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6480 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-ISOPROPYL-5-METHYL-2-HEXENAL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Isopropylmethylhexenal.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
2-Hexenal, 2-isopropyl-5-methyl-
2-Isopropyl-5-methyl-2-hexenal
2-Isopropyl-5-methyl-2-hexen-1-al
5-Methyl-2-(1-methylethyl)-2-hexenal
2-Isopropyl-5-methylhex-2-enal
2-Hexenal, 5-methyl-2-(1-methylethyl)-
α-Isopropyl-β-isobutylacrolein
EC No.: 252-406-4
EINECS 252-406-4
FEMA No. 3406
alpha-Isopropyl-beta-isobutylacrolein
UNII-7F8Q5STQ11
BRN 1752384
MP6450000
252-406-4
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Isopropylmethylhexenal allowed in the EU?
Isopropylmethylhexenal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropylmethylhexenal do in cosmetics?
Isopropylmethylhexenal functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 35158-25-9.
Is Isopropylmethylhexenal used outside cosmetics?
Isopropylmethylhexenal also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isopropylmethylhexenal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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