Moderate Cosmetic Ingredient NOAEL Data

Isotridecyl Isononanoate

INCI: ISOTRIDECYL ISONONANOATE

CAS Number
59231-37-7
Function
Emollient, skin conditioning, smoothing, hair conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed - not prohibited or restricted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Isotridecyl Isononanoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral rat oral REACH
NOAEL 300 mg/kg bw/day oral - oral REACH

Expert Verdict

Low irritation potential; non-comedogenic; well-tolerated by most skin types. Highly branched synthetic ester; colorless to pale yellow liquid; non-oily, nearly dry feel; functions as a silicone oil solubilizer and thickener; absorbs quickly without greasy residue; molecular formula C₂₂H₄₄O₂

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Isotridecyl Isononanoate safe in cosmetics?

Low irritation potential; non-comedogenic; well-tolerated by most skin types. Highly branched synthetic ester; colorless to pale yellow liquid; non-oily, nearly dry feel; functions as a silicone oil solubilizer and thickener; absorbs quickly without greasy residue; molecular formula C₂₂H₄₄O₂ The EU classifies Isotridecyl Isononanoate as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Isotridecyl Isononanoate allowed in the EU?

Isotridecyl Isononanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isotridecyl Isononanoate do in cosmetics?

Isotridecyl Isononanoate functions as: Emollient, skin conditioning, smoothing, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 59231-37-7.

What is the Margin of Safety for Isotridecyl Isononanoate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Isotridecyl Isononanoate?

The NOAEL (No Observed Adverse Effect Level) for Isotridecyl Isononanoate is 300 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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