Moderate Cosmetic Ingredient

Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate

INCI: LACTOBACILLUS/ANGELICA KEISKEI LEAF/STEM EXTRACT FERMENT FILTRATE

CAS Number
Not assigned (KCIA code 22244)
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — no CFR restriction; MoCRA safety substantiation required

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Contains xanthotoxin (CAS 298-81-7), xanthoangelol series, and other prenylated chalcones; phototoxicity risk from furanocoumarins; chalcones have bioactive potentially pharmacological properties; fermentation may alter but not eliminate phototoxic compounds; furanocoumarin and chalcone residue analysis recommended.

⚠️
Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate safe in cosmetics?

Contains xanthotoxin (CAS 298-81-7), xanthoangelol series, and other prenylated chalcones; phototoxicity risk from furanocoumarins; chalcones have bioactive potentially pharmacological properties; fermentation may alter but not eliminate phototoxic compounds; furanocoumarin and chalcone residue analysis recommended. The EU classifies Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate as "restricted". Safety rating: MODERATE.

Is Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate allowed in the EU?

Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate do in cosmetics?

Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (KCIA code 22244).

What is the Margin of Safety for Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Lactobacillus/Angelica Keiskei Leaf/Stem Extract Ferment Filtrate compliance across multiple jurisdictions:

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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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