Lactobacillus/Pueraria Mirifica Root Ferment Filtrate

INCI: LACTOBACILLUS/PUERARIA MIRIFICA ROOT FERMENT FILTRATE

CAS Number
Not assigned
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR restriction; FDA has issued warnings for P. mirifica in dietary supplements due to estrogenic effects

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Pueraria mirifica contains miroestrol and deoxymiroestrol, which are 10× more potent than soy isoflavones at estrogen receptors; adverse events reported include irregular vaginal bleeding and menstrual disorders; contraindicated for estrogen-dependent conditions. Fermentation may or may not degrade these compounds—analytical verification of phytoestrogen content post-fermentation is essential; recommend in-vitro estrogen receptor binding assay (ER-α/ER-β) on finished ferment.

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Concern Level: High

Frequently Asked Questions

Is Lactobacillus/Pueraria Mirifica Root Ferment Filtrate safe in cosmetics?

Pueraria mirifica contains miroestrol and deoxymiroestrol, which are 10× more potent than soy isoflavones at estrogen receptors; adverse events reported include irregular vaginal bleeding and menstrual disorders; contraindicated for estrogen-dependent conditions. Fermentation may or may not degrade these compounds—analytical verification of phytoestrogen content post-fermentation is essential; recommend in-vitro estrogen receptor binding assay (ER-α/ER-β) on finished ferment. The EU classifies Lactobacillus/Pueraria Mirifica Root Ferment Filtrate as "permitted". Safety rating: MODERATE.

Is Lactobacillus/Pueraria Mirifica Root Ferment Filtrate allowed in the EU?

Lactobacillus/Pueraria Mirifica Root Ferment Filtrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lactobacillus/Pueraria Mirifica Root Ferment Filtrate do in cosmetics?

Lactobacillus/Pueraria Mirifica Root Ferment Filtrate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Lactobacillus/Pueraria Mirifica Root Ferment Filtrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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