Lactoglobulin

INCI: LACTOGLOBULIN

CAS Number
9045-23-2 (β-lactoglobulin)
Function
Hair conditioning agent; skin conditioning agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — CIR Expert Panel concluded Lactoglobulin (as part of 16 bovine milk proteins) is safe in the present practices of use and concentration (2022)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Primary concern is Type I (IgE-mediated) hypersensitivity; approximately 15-20% of milk-allergic children remain allergic into adulthood; BSE/TSE sourcing compliance required; hydrolysed forms must control molecular weight to 3500 Da or less to minimize sensitization risk; labelling should flag milk-derived origin

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Lactoglobulin safe in cosmetics?

Primary concern is Type I (IgE-mediated) hypersensitivity; approximately 15-20% of milk-allergic children remain allergic into adulthood; BSE/TSE sourcing compliance required; hydrolysed forms must control molecular weight to 3500 Da or less to minimize sensitization risk; labelling should flag milk-derived origin The EU classifies Lactoglobulin as "permitted". Safety rating: GOOD.

Is Lactoglobulin allowed in the EU?

Lactoglobulin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lactoglobulin do in cosmetics?

Lactoglobulin functions as: Hair conditioning agent; skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 9045-23-2 (β-lactoglobulin).

What is the Margin of Safety for Lactoglobulin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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