Excellent Cosmetic Ingredient NOAEL Data

Starch Acetate

INCI: STARCH ACETATE

CAS Number
9045-28-7
Function
Emollient, hair conditioning, skin conditioning
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; CIR Panel reviewed polysaccharide gums (including starch derivatives) and found them safe as used

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Starch Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 15000 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 30000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 30000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 50000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 22500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
NOAEL 82500 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 82500 mg/kg bw/day oral mouse Chronic COSMOS_DB
NOAEL 82500 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
dose_tested 15000 mg/kg bw/day oral rat Chronic COSMOS_DB

Expert Verdict

Corn-derived — potential concern for individuals with severe corn allergies (rare); inhalation risk in powder form during manufacturing; CIR found safe as used in cosmetics

⚠️
Concern Level: None

Regulatory Flags

fda_food_additive jecfa_safe

Frequently Asked Questions

Is Starch Acetate safe in cosmetics?

Corn-derived — potential concern for individuals with severe corn allergies (rare); inhalation risk in powder form during manufacturing; CIR found safe as used in cosmetics The EU classifies Starch Acetate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is Starch Acetate allowed in the EU?

Starch Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Starch Acetate do in cosmetics?

Starch Acetate functions as: Emollient, hair conditioning, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9045-28-7.

What is the Margin of Safety for Starch Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Starch Acetate?

The NOAEL (No Observed Adverse Effect Level) for Starch Acetate is 15000 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Starch Acetate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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