Good Cosmetic Ingredient NOAEL Data

Lauramide DEA

INCI: LAURAMIDE DEA

CAS Number
120-40-1
Function
Thickener / Viscosity modifier
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR: SQ - JACT 5(5):415-454, 1986; IJT 32(Suppl. 1):36-58, 2013

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Lauramide DEA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 744 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 80 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL >750 mg/kg bw/day oral rat oral REACH
NOAEL 50 mg/kg bw/day dermal code:3543 dermal REACH
NOAEL ca.100 mg/kg bw/day dermal rat dermal REACH
NOAEL 700 mg/kg bw/day oral rat oral REACH
NOAEL >750 mg/kg bw/day oral rat oral REACH
LOAEL ca.100 mg/kg bw/day dermal code:3543 dermal REACH
NOAEL ca.100 mg/kg bw/day dermal rat dermal REACH
NOAEL 700 mg/kg bw/day oral rat oral REACH

Expert Verdict

Good safety profile with minimal skin penetration; generally considered safe for cosmetic use.

⚠️
Concern Level: Low

Regulatory Flags

eu_children_restricted fda_food_additive

Frequently Asked Questions

Is Lauramide DEA safe in cosmetics?

Good safety profile with minimal skin penetration; generally considered safe for cosmetic use. The EU classifies Lauramide DEA as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Lauramide DEA allowed in the EU?

Lauramide DEA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lauramide DEA do in cosmetics?

Lauramide DEA functions as: Thickener / Viscosity modifier. It is classified as a Cosmetic Ingredient in our database. CAS number: 120-40-1.

What is the Margin of Safety for Lauramide DEA?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Lauramide DEA?

The NOAEL (No Observed Adverse Effect Level) for Lauramide DEA is 744 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Lauramide DEA compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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