GOOD Cosmetic Ingredient GHS Classified Dermal Penetration

Benzoyl Peroxide Regulatory &

Also known as: Akneroxid 5, Asidopan, Aztec BPO, Benoxyl (5&10) Lotion, Benzoic acid, peroxide (+15 more)

INCI: BENZOYL PEROXIDE

Benzoyl Peroxide Regulatory & (CAS 94-36-0) is a cosmetic cosmetic ingredient functioning as Insufficient Data. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 94-36-0 →

Cross-Vertical Regulatory Divergence

Benzoyl Peroxide Regulatory & is classified GHS Danger (H241, H317, H319, H400, H410, H335, H316) in the chemicals database but is restricted in EU cosmetics.

Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code

CAS Number

94-36-0

View industrial chemical safety profile →

Function

Insufficient Data

Editorial assessment

GOOD

Preliminary editorial note — not a computed safety verdict.

Chemistry & Identifiers

Formula

C14H10O4

242.23 g/mol

EC Number

202-327-6

PubChem CID

7187

IUPAC Name

benzoyl benzenecarboperoxoate

InChIKey

OMPJBNCRMGITSC-UHFFFAOYSA-N

ChEBI: CHEBI:82405 UNII: W9WZN9A0GM Wikidata: Q411424

Regulatory Status

EU EU Status restricted

US US Status restricted

US Notes OTC drug classification; no specific concentration restrictions

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Benzoyl Peroxide Regulatory &.

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects

The substance is irritating to the eyes, skin and respiratory tract.

Long-term Exposure Effects

Repeated or prolonged contact may cause skin sensitization.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Benzoyl Peroxide Regulatory & across SCCS product categories, with measured dermal absorption where available.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Benzoyl Peroxide Regulatory &, relevant to systemic exposure and MoS calculations.

Absorption %

10-20%

Penetration Level

epidermis

Penetration Depth

epidermis

Molecular Weight

242.2 Da

Log P

1.67

Systemic Absorption

minimal

Topical Bioavailability

6-16%

Safety Margin Factor

moderate

Vehicle Dependent

Yes — absorption varies by formulation

Source: SCCS Opinion

IARC Carcinogenicity

International Agency for Research on Cancer (WHO) monograph evaluation.

IARC Group

Volume

36, Sup 7, 71

Evaluation Year

1998

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word

Danger

Pictograms

ExplosiveFlammableHarmful / IrritantEnvironmental Hazard

Hazard Class and Category

Org. Perox. B; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

Hazard Statements

H241
H319 Causes serious eye irritation
H317 May cause an allergic skin reaction
H400 Very toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects

Specific Concentration Limits / M-factors

M = 10; M = 10

Inserted via ATP: ATP22

Sensitization AOP Dashboard

Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.

DPRA Cys %

100%

DPRA Lys %

81.3%

KeratinoSens IC50

567.615 µM

hCLAT CV75

41 µg/mL

LLNA EC3

0.043%

NESIL

14177 µg/cm²

LLNA: Strong (1A) GHS: 1A Human: positive

Source: LLNA: Kimber et al. (1998); DPRA: Gerberick et al. 2007 [DOI:10.1093/toxsci/kfm064]; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868] | Emter et al. 2010 [DOI:10.1016/j.taap.2010.03.009]; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]; HPPT: [791] Poole RL et al. (1970): https://jamanetwork.com/journals/jamadermatology/article-abstract/531

HRIPT Human Patch Test Studies

2 human repeat insult patch tests aggregated from dermatological literature.

Test Type	N	Sensitized	Dose µg/cm²	NESIL µg/cm²	Potency
HRIPT	-	0	14177.16	-	-
OECD_DA_Human	-	0	-	-	1B (Weak sensitizer)

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1,000 - 10,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Hazard classification: Restricted (Annex XVII)

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

SA Saudi SFDA (III - Restricted)

Product type: Artificial nail systems. Max: 0.7% (after mixing for use).

BRIN Brazil/India Cosmetics

Brazil: Prohibited

India: Restricted · max 0.7% (after mixing for use)

Additional Jurisdictional Restrictions (6)

Jurisdiction	Status	Max %	Product Type
CN	banned	-	-
AU	therapeutic_good	5.0	acne treatment
CA	restricted	10%	Nail products (catalyst); hair dyes only
CA	drug_classification	-	-
ASEAN	restricted	0.7% after mixing	Artificial nail systems
KR	prohibited	-	-

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (4)

Carcinogen Classification

Benzoyl peroxide | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 36: (1985) Allyl Compounds, Aldehydes, Epoxides and Peroxides | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide…

Source: International Agency for Research on Cancer (IARC)

Evidence for Carcinogenicity

Evaluation: There is inadequate evidence in humans for the carcinogenicity of benzoyl peroxide. There is limited evidence in experimental animals for the carcinogenicity of benzoyl peroxide. Overall evaluation: Benzoyl peroxide is not classifiable as to its carcinogenicity to humans (Group 3). | A4: Not classifiable as a human carcinogen.

Source: Hazardous Substances Data Bank (HSDB)

ICSC Safety Card

0225

Source: WHO/JECFA

Skin Eye Respiratory Irritation

An allergen and eye irritant. | Benzoyl peroxide dust irritates the eyes of albino rabbits ... . | Potential symptoms of overexposure are irritation of skin, eyes and mucous membranes ... . | In an investigation made in a plant located in New York state where benzoyl peroxide formulations were being processed ... no objectionable subjective symptoms /were experienced/ when exposed to dust…

Source: Hazardous Substances Data Bank (HSDB)

Regulatory (1)

JECFA Evaluation

Source: WHO/JECFA

Function Categories & List Membership

Cosmetic/Chemical Function Categories

Adhesion/cohesion promoter Catalyst Chemical reaction regulator Dye Food preservative Hardener Oxidizing agent Pharmaceutical

Regulatory List Membership (2)

FDA Substances Added to Food (EAFUS) EU CosIng Cosmetics Ingredient Database

Editorial summary

Preliminary editorial summary for Benzoyl Peroxide Regulatory & — not a computed safety verdict. See the sourced toxicological data above.

Regulatory Flags

EU Restricted fda_food_additive eu_cosing_listed

Known Synonyms

Akneroxid 5 Asidopan Aztec BPO Benoxyl (5&10) Lotion Benzoic acid, peroxide Benzol peroxide Cadat BPO Cadox BS Clearasil Antibacterial Acne Lotion Clearasil BP Acne Treatment Cream Duresthin 5 EINECS 202-327-6 Epi Clear Antiseptic Lotion Incidol Luperox FL Mytolac Nayper B and BO Nayper bo Norox bzp-C-35 Norox bzp-250

Chemical Function

Oxidizing agent Pharmaceutical Adhesion/cohesion promoter Catalyst

Regulatory Lists

active_ingredient; Australia inert_ingredient; non_food_use; Pesticides food_additive; Substances Added to Food (formerly EAFUS) (2/2019) Canada; pharmaceutical consumer_product; Europe drinking_water; Europe; manufacturing; plastic_additive active_ingredient; Europe; Pesticides Europe; Personal care; restricted

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound

BENZOYL PEROXIDE

ChEMBL ID

CHEMBL1200370

Max Phase

Adverse Event Associations

198

View full pharmaceutical profile →

Frequently Asked Questions

Is Benzoyl Peroxide Regulatory & safe in cosmetics?

Benzoyl Peroxide Regulatory & has a safety rating of "GOOD" in our database. EU status: restricted. US status: restricted.

Is Benzoyl Peroxide Regulatory & allowed in the EU?

Benzoyl Peroxide Regulatory & EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Benzoyl Peroxide Regulatory & do in cosmetics?

Benzoyl Peroxide Regulatory & functions as: Insufficient Data. It is classified as a cosmetic ingredient in our database. CAS number: 94-36-0.

Is Benzoyl Peroxide Regulatory & used outside cosmetics?

Benzoyl Peroxide Regulatory & also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Benzoyl Peroxide Regulatory & have different safety status in cosmetics vs industrial chemicals?

Benzoyl Peroxide Regulatory & is classified GHS Danger (H241, H317, H319, H400, H410, H335, H316) in the chemicals database but is restricted in EU cosmetics.

Compliance Tools

Check Benzoyl Peroxide Regulatory & compliance across multiple jurisdictions:

Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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