Poor Cosmetic Ingredient GHS Classified Sensitization Data

Methyldibromo Glutaronitrile

INCI: METHYLDIBROMO GLUTARONITRILE

CAS Number
35691-65-7
Function
Broad-spectrum antimicrobial preservative (bacteria, yeasts, molds)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes No specific FDA restriction; CIR reaffirmed (2017) safe in rinse-off and safe at <0.025% in leave-on; US use at 0.005-0.04%

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by ingestion.

Sensitization Profile

Contact sensitization data for Methyldibromo Glutaronitrile based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
2.0%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis

Source: Banned EU; ESSCA

Expert Verdict

Banned in the EU since 2007 due to rising contact allergy rates and inability to establish a safe use level; restricted in the US with concentration limits for leave-on products.

⚠️
Concern Level: High

Regulatory Flags

Allergen

Frequently Asked Questions

Is Methyldibromo Glutaronitrile safe in cosmetics?

Banned in the EU since 2007 due to rising contact allergy rates and inability to establish a safe use level; restricted in the US with concentration limits for leave-on products. The EU classifies Methyldibromo Glutaronitrile as "prohibited". Safety rating: POOR.

Is Methyldibromo Glutaronitrile allowed in the EU?

Methyldibromo Glutaronitrile EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyldibromo Glutaronitrile do in cosmetics?

Methyldibromo Glutaronitrile functions as: Broad-spectrum antimicrobial preservative (bacteria, yeasts, molds). It is classified as a Cosmetic Ingredient in our database. CAS number: 35691-65-7.

What is the Margin of Safety for Methyldibromo Glutaronitrile?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Methyldibromo Glutaronitrile compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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