Liquiritin Apioside

INCI: LIQUIRITIN APIOSIDE

CAS Number
74639-14-8
Function
Skin conditioning, skin lightening/brightening (flavonoid active)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed as a cosmetic ingredient; no specific prohibitions. Not classified as an OTC drug active.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited cosmetic-specific toxicology data. As a licorice-derived flavonoid, it is generally considered low-risk. May cause sensitization in individuals with Glycyrrhiza allergy. No known phototoxicity.. A flavonoid glycoside (liquiritigenin 4′-apiosylglucoside) isolated from licorice root (Glycyrrhiza spp.). Molecular formula C₂₆H₃₀O₁₃, MW 550.51. Exhibits antitussive effects in pharmacological studies. In cosmetics, valued for tyrosinase inhibition and skin-brightening activity. Related to l...

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Liquiritin Apioside safe in cosmetics?

Limited cosmetic-specific toxicology data. As a licorice-derived flavonoid, it is generally considered low-risk. May cause sensitization in individuals with Glycyrrhiza allergy. No known phototoxicity.. A flavonoid glycoside (liquiritigenin 4′-apiosylglucoside) isolated from licorice root (Glycyrrhiza spp.). Molecular formula C₂₆H₃₀O₁₃, MW 550.51. Exhibits antitussive effects in pharmacological studies. In cosmetics, valued for tyrosinase inhibition and skin-brightening activity. Related to l... The EU classifies Liquiritin Apioside as "permitted". Safety rating: MODERATE.

Is Liquiritin Apioside allowed in the EU?

Liquiritin Apioside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Liquiritin Apioside do in cosmetics?

Liquiritin Apioside functions as: Skin conditioning, skin lightening/brightening (flavonoid active). It is classified as a cosmetic ingredient in our database. CAS number: 74639-14-8.

What is the Margin of Safety for Liquiritin Apioside?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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