Regulatory Status
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Safety Data
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Expert Verdict
Lithospermum extract from Boraginaceae family carries risk of pyrrolizidine alkaloid (PA) contamination, which are hepatotoxic and genotoxic; SCCS and EFSA recommend PA limits in cosmetics; shikonin is pharmacologically active with anti-inflammatory and cytotoxic effects at high concentrations; PA testing strongly recommended before use.
Regulatory Flags
Frequently Asked Questions
Is Lithospermum Extract safe in cosmetics?
Lithospermum extract from Boraginaceae family carries risk of pyrrolizidine alkaloid (PA) contamination, which are hepatotoxic and genotoxic; SCCS and EFSA recommend PA limits in cosmetics; shikonin is pharmacologically active with anti-inflammatory and cytotoxic effects at high concentrations; PA testing strongly recommended before use. The EU classifies Lithospermum Extract as "permitted". Safety rating: MODERATE.
Is Lithospermum Extract allowed in the EU?
Lithospermum Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lithospermum Extract do in cosmetics?
Lithospermum Extract functions as: Skin conditioning; contains shikonin/alkannin naphthoquinone pigments. It is classified as a cosmetic ingredient in our database.
What is the Margin of Safety for Lithospermum Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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