Regulatory Status
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Safety Data
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Expert Verdict
Synthetic modified nucleoside with no CIR review or SCCS opinion; full toxicological dossier required including acute, repeat-dose, genotoxicity, sensitization, and irritation studies; cosmetic relevance unproven.
Regulatory Flags
Frequently Asked Questions
Is Locked Nucleic Acid-1 safe in cosmetics?
Synthetic modified nucleoside with no CIR review or SCCS opinion; full toxicological dossier required including acute, repeat-dose, genotoxicity, sensitization, and irritation studies; cosmetic relevance unproven. The EU classifies Locked Nucleic Acid-1 as "permitted". Safety rating: POOR.
Is Locked Nucleic Acid-1 allowed in the EU?
Locked Nucleic Acid-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Locked Nucleic Acid-1 do in cosmetics?
Locked Nucleic Acid-1 functions as: Not established for cosmetic use (LNA-type nucleoside derivative; primarily pharmaceutical/research). It is classified as a cosmetic ingredient in our database. CAS number: 206055-71-2 [^1_5].
What is the Margin of Safety for Locked Nucleic Acid-1?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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