Is Magnesium Gluconate safe in cosmetics?
Magnesium Gluconate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Magnesium Gluconate
INCI: MAGNESIUM GLUCONATE
Magnesium Gluconate (CAS 3632-91-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 3632-91-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
magnesium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
InChIKey
CTUVIUYTHWPELF-IYEMJOQQSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - no specific prohibition; also has GRAS status in food, supporting its safety profile in cosmetics.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Magnesium Gluconate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
MAGNESIUM GLUCONATE | 1998 | NOT SPECIFIED | Group ADI for glucono delta-lactone, calcium gluconate, magnesium gluconate, potassium gluconate, and sodium gluconate | TRS 891-JECFA 51/46 | FAS 42-JECFA 51/203
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
No specific technical function
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Magnesium Gluconate.
Regulatory Flags
potential-allergen
fda_food_additive
jecfa_safe
Chemical Function
Softener and conditioner
No specific technical function
Flavouring and nutrient
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Magnesium gluconate
E Number
E580
ADI
NOT SPECIFIED mg/kg bw
Food Category
flavor_enhancer
Frequently Asked Questions
Is Magnesium Gluconate allowed in the EU?
Magnesium Gluconate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Magnesium Gluconate do in cosmetics?
Magnesium Gluconate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 3632-91-5.
Is Magnesium Gluconate used outside cosmetics?
Magnesium Gluconate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Magnesium Gluconate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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