Maleic Anhydride

Strong skin and mucous membrane irritant. Maleic acid (hydrolysis product) caused acute vascular dermatitis in 17 of 50 test subjects after 6 weeks of topical application and inflammatory skin responses at 24- and 48-hour marks. Corrosive in neat form. Respiratory sensitizer upon inhalation. Highly reactive cyclic acid anhydride. Hydrolyzes rapidly to maleic acid in the presence of water. Its primary cosmetic relevance is as a building block for maleated derivatives (maleated soybean oil, mal... The EU classifies Maleic Anhydride as "prohibited". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Maleic Anhydride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

Maleic Anhydride functions as: Chemical intermediate/monomer in cosmetic polymer synthesis; not typically used directly in finished cosmetics. It is classified as a cosmetic ingredient in our database. CAS number: 108-31-6.

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

The NOAEL (No Observed Adverse Effect Level) for Maleic Anhydride is 40 mg/kg bw/day based on a Subchronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.

Maleic Anhydride carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed May be harmful in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause damage to lungs if inhaled Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.