Mandragora Officinarum Root Extract

INCI: MANDRAGORA OFFICINARUM ROOT EXTRACT

CAS Number
90063-85-7
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition. However, if the extract imparts pharmacological effects (e.g., via tropane alkaloids), the finished product could be classified as a drug rather than a cosmetic, triggering drug-level regulatory requirements.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Significant - contains tropane alkaloids (atropine, scopolamine, hyoscyamine) that are toxic and pharmacologically active. Percutaneous absorption potential must be evaluated. Alkaloid content must be controlled and documented to remain within cosmetic-safe thresholds. Not suitable for products applied to mucous membranes or damaged skin.. Mandrake root - one of the most historically significant plants in herbalism and folklore. Contains potent alkaloids that historically served as sedatives ...

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Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Mandragora Officinarum Root Extract safe in cosmetics?

Significant - contains tropane alkaloids (atropine, scopolamine, hyoscyamine) that are toxic and pharmacologically active. Percutaneous absorption potential must be evaluated. Alkaloid content must be controlled and documented to remain within cosmetic-safe thresholds. Not suitable for products applied to mucous membranes or damaged skin.. Mandrake root - one of the most historically significant plants in herbalism and folklore. Contains potent alkaloids that historically served as sedatives ... The EU classifies Mandragora Officinarum Root Extract as "permitted". Safety rating: MODERATE.

Is Mandragora Officinarum Root Extract allowed in the EU?

Mandragora Officinarum Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Mandragora Officinarum Root Extract do in cosmetics?

Mandragora Officinarum Root Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 90063-85-7.

What is the Margin of Safety for Mandragora Officinarum Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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