Also known as: EINECS 285-377-1, Tea tree ext.
INCI: MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF
Melaleuca Alternifolia (Tea Tree) Leaf (CAS 85085-48-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning - emollient (softens and smoothens the skin). Reported NOAEL =45 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 85085-48-9 →
Melaleuca Alternifolia (Tea Tree) Leaf is classified GHS Danger (H226, H302, H304, H315, H317, H319, H411) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Melaleuca Alternifolia (Tea Tree) Leaf.
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for Melaleuca Alternifolia (Tea Tree) Leaf. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =45 mg/kg bw/day | oral | Rat | short-term | ECHA |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Preliminary editorial summary for Melaleuca Alternifolia (Tea Tree) Leaf — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Melaleuca Alternifolia (Tea Tree) Leaf by CAS number or substance name.
Same-CAS public records found in food safety data.
Same-CAS food additive or FDA GRAS records from the core public database.
Melaleuca Alternifolia (Tea Tree) Leaf has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Melaleuca Alternifolia (Tea Tree) Leaf EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
Melaleuca Alternifolia (Tea Tree) Leaf functions as: Skin conditioning - emollient (softens and smoothens the skin). It is classified as a cosmetic ingredient in our database. CAS number: 85085-48-9.
The NOAEL (No Observed Adverse Effect Level) for Melaleuca Alternifolia (Tea Tree) Leaf is =45 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ECHA.
Melaleuca Alternifolia (Tea Tree) Leaf also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Melaleuca Alternifolia (Tea Tree) Leaf is classified GHS Danger (H226, H302, H304, H315, H317, H319, H411) in the chemicals database but is restricted in EU cosmetics.
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