Is Menaquinone-7 safe in cosmetics?
Menaquinone-7 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Menaquinone-7
INCI: MENAQUINONE-7
Menaquinone-7 (CAS 2124-57-4) is a cosmetic cosmetic ingredient functioning as Astringent, anti-sebum, bleaching (skin lightening), skin protecting. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Astringent, anti-sebum, bleaching (skin lightening), skin protecting
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione
InChIKey
RAKQPZMEYJZGPI-LJWNYQGCSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - not prohibited or restricted for cosmetic use; also has GRAS recognition as vitamin K₂ in food/supplements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Menaquinone-7.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Astringent
Bleaching agent
Humectant
Pharmaceutical
UV stabilizer
Editorial summary
Preliminary editorial summary for Menaquinone-7 — not a computed safety verdict. See the sourced toxicological data above.
Chemical Function
Humectant
Astringent
UV stabilizer
Pharmaceutical
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MENAQUINONE 7
ChEMBL ID
CHEMBL1230575
Max Phase
2
Adverse Event Associations
20
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Vitamin K2 - MK-7 (Menaquinone-7)
FDA GRAS
At the notifier's request, FDA ceased to evaluate this notice
GRN
245
Food Category
vitamins_minerals
As a nutrient supplement in dairy products, margarine substitutes, and dairy products including yoghurt, cottage cheese, hard cheeses, milk drinks and substitute products at levels up to 50 micrograms per day
View full food safety profile →Frequently Asked Questions
Is Menaquinone-7 allowed in the EU?
Menaquinone-7 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Menaquinone-7 do in cosmetics?
Menaquinone-7 functions as: Astringent, anti-sebum, bleaching (skin lightening), skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: 2124-57-4.
Is Menaquinone-7 used outside cosmetics?
Menaquinone-7 also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Menaquinone-7 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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