Is Mentha Piperita Oil safe in cosmetics?
Mentha Piperita Oil has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Mentha Piperita Oil
Also known as: Mentha Piperita (Peppermint) Leaf Water, EC No.: 616-900-7, English black mint oil, FEMA No. 2848, Peppermint oleoresin/extract (Mentha piperita L.) (+3 more)
INCI: MENTHA PIPERITA OIL
Mentha Piperita Oil (CAS 8006-90-4) is a cosmetic cosmetic ingredient functioning as Masking, Perfuming, Refreshing, Soothing. Reported NOAEL =40 mg/kg/d in rat (CIR_vision_codex); EU Regulation 1223/2009 status: restricted, max Multiple fragrance allergen components require disclosure >30 ppm in leave-on products. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 8006-90-4 →
Auto-generated CPSR Part A draft with source citations
Function
Masking, Perfuming, Refreshing, Soothing
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
EU Max Conc.
Multiple fragrance allergen components require disclosure >30 ppm in leave-on products
US US Status
permitted
US Notes
14% rosacea irritancy rate. Menthol content is TRPA1/TRPV1 agonist. Avoid in rosacea formulations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Mentha Piperita Oil.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Mentha Piperita Oil. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =40 mg/kg/d | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =40 mg/kg/d | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =40 mg/kg/d | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =40 mg/kg/d | - | rat | NOAEL study | CIR_vision_codex |
Sensitization Profile
Contact sensitization data for Mentha Piperita Oil based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: IFRA
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =2426 mg/kg | Rat | oral | - | TEST |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "IFRA"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Deodorizer
Dye
Flavouring and nutrient
Fragrance
Humectant
Softener and conditioner
Regulatory List Membership (4)
EU Regulated in Personal Care
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Mentha Piperita Oil.
Regulatory Flags
rosacea-avoid
trpv1-trpa1-agonist
menthol-source
nrs-14pct-irritancy
essential-oil
flushing-trigger
do-not-formulate-for-rosacea
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Mentha Piperita Oil by CAS number or substance name.
Studies
4
Lowest NOAEL
40 mg/kg/d
Highest NOAEL
40 mg/kg/d
CIR_vision_codex
Known Synonyms
Mentha Piperita (Peppermint) Leaf Water
EC No.: 616-900-7
English black mint oil
FEMA No. 2848
Peppermint oleoresin/extract (Mentha piperita L.)
Pfefferminz oel
UNII-AV092KU4JH
Mentharil
Chemical Function
Fragrance
Deodorizer
Humectant
Softener and conditioner
Flavouring and nutrient
Biocide
Regulatory Lists
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care - oral and dental care - teeth whitener
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
IFRA Transparency
IFRA Transparency
IFRA Transparency
active_ingredient; Australia
Europe; Personal care - body oil
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
285
Frequently Asked Questions
Is Mentha Piperita Oil allowed in the EU?
Mentha Piperita Oil EU regulatory status: restricted. Maximum allowed concentration: Multiple fragrance allergen components require disclosure >30 ppm in leave-on products. This is based on EU Regulation 1223/2009 and its amendments.
What does Mentha Piperita Oil do in cosmetics?
Mentha Piperita Oil functions as: Masking, Perfuming, Refreshing, Soothing. It is classified as a cosmetic ingredient in our database. CAS number: 8006-90-4.
What is the NOAEL for Mentha Piperita Oil?
The NOAEL (No Observed Adverse Effect Level) for Mentha Piperita Oil is =40 mg/kg/d based on a NOAEL study study via oral route in rat. A total of 4 study endpoints are available. Source: CIR_vision_codex.
Is Mentha Piperita Oil used outside cosmetics?
Mentha Piperita Oil also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Mentha Piperita Oil compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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