Moderate Cosmetic Ingredient

Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1

INCI: METHIONYL SH-POLYPEPTIDE-7 ALANYL SR-SPIDER OLIGOPEPTIDE-1

CAS Number
for any of them - this complicates ASEAN and certain Asian market registrations where CAS is often expected.
Function
Emollient, Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed - not specifically prohibited or restricted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No documented adverse effects; the spider-derived peptide component is novel with minimal independent safety assessment; prevalence in commercial products is essentially 0%. Unique dual-initiation construct - contains both methionine and alanine initiation codes; 242 amino acids; fuses sh-Polypeptide-7 (a keratinocyte growth factor) with sr-Spider Oligopeptide-1 (spider silk-derived bioactive peptide); one of the largest fusion peptides in the CosIng database for cosmetic use

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Concern Level: Moderate

Frequently Asked Questions

Is Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1 safe in cosmetics?

No documented adverse effects; the spider-derived peptide component is novel with minimal independent safety assessment; prevalence in commercial products is essentially 0%. Unique dual-initiation construct - contains both methionine and alanine initiation codes; 242 amino acids; fuses sh-Polypeptide-7 (a keratinocyte growth factor) with sr-Spider Oligopeptide-1 (spider silk-derived bioactive peptide); one of the largest fusion peptides in the CosIng database for cosmetic use The EU classifies Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1 as "permitted". Safety rating: MODERATE.

Is Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1 allowed in the EU?

Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1 do in cosmetics?

Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1 functions as: Emollient, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: for any of them - this complicates ASEAN and certain Asian market registrations where CAS is often expected..

What is the Margin of Safety for Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Methionyl sh-Polypeptide-7 Alanyl sr-Spider Oligopeptide-1 compliance across multiple jurisdictions:

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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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