Moderate Cosmetic Ingredient

Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2

INCI: METHIONYL SH-POLYPEPTIDE-7 SH-OLIGOPEPTIDE-1 SH-OLIGOPEPTIDE-2

CAS Number
None assigned
Function
Skin conditioning (anti-aging)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed - general cosmetic ingredient, no specific prohibition

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Same E. coli fermentation-derived recombinant protein concerns as #1 (endotoxin control, host-cell protein residuals, batch-to-batch consistency). This is NEXGEN's "NEX-GEI" trade product - a triple fusion of recombinant hGH (sh-Polypeptide-7), EGF (sh-Oligopeptide-1), and IGF-1 (sh-Oligopeptide-2); 315 amino acids. Designed to deliver combined growth-factor signaling for enhanced skin renewal.

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Concern Level: Moderate

Frequently Asked Questions

Is Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2 safe in cosmetics?

Same E. coli fermentation-derived recombinant protein concerns as #1 (endotoxin control, host-cell protein residuals, batch-to-batch consistency). This is NEXGEN's "NEX-GEI" trade product - a triple fusion of recombinant hGH (sh-Polypeptide-7), EGF (sh-Oligopeptide-1), and IGF-1 (sh-Oligopeptide-2); 315 amino acids. Designed to deliver combined growth-factor signaling for enhanced skin renewal. The EU classifies Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2 as "permitted". Safety rating: MODERATE.

Is Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2 allowed in the EU?

Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2 do in cosmetics?

Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2 functions as: Skin conditioning (anti-aging). It is classified as a cosmetic ingredient in our database. CAS number: None assigned.

What is the Margin of Safety for Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Methionyl sh-Polypeptide-7 sh-Oligopeptide-1 sh-Oligopeptide-2 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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