Methionyl sh-Polypeptide-9 Decapeptide-40

INCI: METHIONYL SH-POLYPEPTIDE-9 DECAPEPTIDE-40

CAS Number
None assigned
Function
Skin conditioning / hair conditioning (fusion of VEGFA analog with carrier peptide)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Same biotech-origin concerns as #4; Decapeptide-40 fusion may enhance penetration, making concentration control even more critical for the angiogenic VEGFA component. Combines the VEGFA-mimicking activity of sh-Polypeptide-9 with Decapeptide-40 as a penetration/stability-enhancing fusion partner. The design mirrors other NEXGEN-style recombinant fusions pairing a bioactive polypeptide with a functional decapeptide.

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Concern Level: Moderate

Frequently Asked Questions

Is Methionyl sh-Polypeptide-9 Decapeptide-40 safe in cosmetics?

Same biotech-origin concerns as #4; Decapeptide-40 fusion may enhance penetration, making concentration control even more critical for the angiogenic VEGFA component. Combines the VEGFA-mimicking activity of sh-Polypeptide-9 with Decapeptide-40 as a penetration/stability-enhancing fusion partner. The design mirrors other NEXGEN-style recombinant fusions pairing a bioactive polypeptide with a functional decapeptide. The EU classifies Methionyl sh-Polypeptide-9 Decapeptide-40 as "permitted". Safety rating: MODERATE.

Is Methionyl sh-Polypeptide-9 Decapeptide-40 allowed in the EU?

Methionyl sh-Polypeptide-9 Decapeptide-40 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methionyl sh-Polypeptide-9 Decapeptide-40 do in cosmetics?

Methionyl sh-Polypeptide-9 Decapeptide-40 functions as: Skin conditioning / hair conditioning (fusion of VEGFA analog with carrier peptide). It is classified as a cosmetic ingredient in our database. CAS number: None assigned.

What is the Margin of Safety for Methionyl sh-Polypeptide-9 Decapeptide-40?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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