Methoxyacetophenone

INCI: METHOXYACETOPHENONE

CAS Number
Multiple isomers exist - 2'-methoxyacetophenone is CAS 579-74-8 (confirmed via PubChem); 4'-methoxyacetophenone (p-acetylanisole) is CAS 100-06-1. The INCI name in CosIng may encompass the predominant isomer - verify with CosIng for the exact CAS assignment
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - not specifically prohibited; GRAS status may apply for some isomers in flavoring context

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Potential skin sensitizer at high concentrations; general fragrance allergen risk per SCCS guidelines. Aromatic ketone with a methoxy substituent on the phenyl ring. The 4'-isomer (p-acetylanisole) has a characteristic sweet, hawthorn/anise-like scent widely used in perfumery

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Methoxyacetophenone safe in cosmetics?

Potential skin sensitizer at high concentrations; general fragrance allergen risk per SCCS guidelines. Aromatic ketone with a methoxy substituent on the phenyl ring. The 4'-isomer (p-acetylanisole) has a characteristic sweet, hawthorn/anise-like scent widely used in perfumery The EU classifies Methoxyacetophenone as "permitted". Safety rating: MODERATE.

Is Methoxyacetophenone allowed in the EU?

Methoxyacetophenone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methoxyacetophenone do in cosmetics?

Methoxyacetophenone functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: Multiple isomers exist - 2'-methoxyacetophenone is CAS 579-74-8 (confirmed via PubChem); 4'-methoxyacetophenone (p-acetylanisole) is CAS 100-06-1. The INCI name in CosIng may encompass the predominant isomer - verify with CosIng for the exact CAS assignment.

What is the Margin of Safety for Methoxyacetophenone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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