Is Methyl Acetoacetate safe in cosmetics?
Methyl Acetoacetate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Methyl Acetoacetate
Also known as: Butanoic acid, 3-oxo-, methyl ester, Acetoacetic methyl ester, EINECS 203-299-8, Methyl acetylacetonate, Methylacetoacetate (+2 more)
INCI: METHYL ACETOACETATE
Methyl Acetoacetate (CAS 105-45-3) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient, solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 105-45-3 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient, solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
methyl 3-oxobutanoate
InChIKey
WRQNANDWMGAFTP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - no FDA cosmetic prohibition; FEMA GRAS status for flavor use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Acetoacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. Exposure could cause lowering of consciousness.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Eye Irrit. 2
Hazard Statements
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5400 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1086
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Methyl... acetoacetate may be irritating /to eyes and skin/.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Acetoacetate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
Butanoic acid, 3-oxo-, methyl ester
Acetoacetic methyl ester
EINECS 203-299-8
Methyl acetylacetonate
Methylacetoacetate
Methylester kyseliny acetoctove
UNII-CW4I82QAX1
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186053
Frequently Asked Questions
Is Methyl Acetoacetate allowed in the EU?
Methyl Acetoacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Acetoacetate do in cosmetics?
Methyl Acetoacetate functions as: Fragrance ingredient, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 105-45-3.
Is Methyl Acetoacetate used outside cosmetics?
Methyl Acetoacetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methyl Acetoacetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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