Methyl Acetoacetate
INCI: METHYL ACETOACETATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Methyl Acetoacetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Low toxicity profile; mild skin and eye irritant at concentrated levels; no significant sensitization concerns at typical use levels. Beta-keto ester with a pleasant, fruity-ethereal odor; serves as a versatile synthetic building block; also used in food flavoring
Regulatory Flags
Frequently Asked Questions
Is Methyl Acetoacetate safe in cosmetics?
Low toxicity profile; mild skin and eye irritant at concentrated levels; no significant sensitization concerns at typical use levels. Beta-keto ester with a pleasant, fruity-ethereal odor; serves as a versatile synthetic building block; also used in food flavoring The EU classifies Methyl Acetoacetate as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Methyl Acetoacetate allowed in the EU?
Methyl Acetoacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Acetoacetate do in cosmetics?
Methyl Acetoacetate functions as: Fragrance ingredient, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 105-45-3.
What is the Margin of Safety for Methyl Acetoacetate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Acetoacetate?
The NOAEL (No Observed Adverse Effect Level) for Methyl Acetoacetate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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