Moderate Cosmetic Ingredient NOAEL Data

Methyl Benzodioxepinone

INCI: METHYL BENZODIOXEPINONE

CAS Number
28940-11-6
Function
Masking, perfuming (fragrance)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed - no prohibition or restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Methyl Benzodioxepinone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=15000 ppm oral rat oral REACH

Expert Verdict

General fragrance sensitization considerations; no specific high-risk flags in current literature. Synthetic fragrance compound; molecular formula C₁₀H₁₀O₃

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is Methyl Benzodioxepinone safe in cosmetics?

General fragrance sensitization considerations; no specific high-risk flags in current literature. Synthetic fragrance compound; molecular formula C₁₀H₁₀O₃ The EU classifies Methyl Benzodioxepinone as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Methyl Benzodioxepinone allowed in the EU?

Methyl Benzodioxepinone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Benzodioxepinone do in cosmetics?

Methyl Benzodioxepinone functions as: Masking, perfuming (fragrance). It is classified as a cosmetic ingredient in our database. CAS number: 28940-11-6.

What is the Margin of Safety for Methyl Benzodioxepinone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methyl Benzodioxepinone?

The NOAEL (No Observed Adverse Effect Level) for Methyl Benzodioxepinone is >=15000 ppm based on a oral study via oral route in rat. Source: REACH.

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